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Chronic lung function decline in cotton textile workers: roles of historical and recent exposures to endotoxin.

Authors
Shi-J; Mehta-AJ; Hang-J-Q; Zhang-H; Dai-H; Su-L; Eisen-EA; Christiani-DC
Source
Environ Health Perspect 2010 Nov; 118(11):1620-1624
NIOSHTIC No.
20038754
Abstract
BACKGROUND: Long-term occupational exposure to cotton dust that contains endotoxin is associated with chronic respiratory symptoms and excessive decline in forced expiratory volume in 1 sec (FEV1), but the mechanisms of endotoxin-related chronic airflow obstruction remain unclear. OBJECTIVE: In the current study, we examined temporal aspects of the exposure-response relationship between airborne endotoxin exposure, longitudinal change in FEV1, and respiratory symptoms in a cohort of Chinese cotton textile workers. METHODS: This prospective cohort study followed 447 cotton textile workers from 1981 to 2006. at approximately 5-year intervals. We used a generalized estimating equations approach to model FEV1 level and respiratory symptoms as a function of past exposure (cumulative exposure up to the start of the most recent 5-year survey interval) and cumulative exposure (within the most recent interval) to endotoxins, after adjusting for other covariates. Models were stratified by active versus retired work status and by years employed before the baseline survey (< 5 and > or = 5 years). RESULTS AND CONCLUSIONS: Past exposure to endotoxin was associated with reduced FEV1 level among retired cotton workers. Among all cotton workers, past exposure was more strongly associated with reduced FEV1 for those hired < 5 years before baseline than for those who were hired > or = 5 years after baseline. Recent endotoxin exposure was significantly associated with byssinosis, chronic bronchitis, and chronic cough.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Lung-function; Endotoxins; Textile-mills; Textile-workers; Textiles; Textiles-industry; Cotton-dust; Cotton-fibers; Cotton-industry; Cotton-mill-workers; Breathing; Respiration; Respiratory-rate; Air-flow; Airborne-dusts; Airway-obstruction; Exposure-assessment; Dose-response; Workplace-studies; Byssinosis; Author Keywords: byssinosis; China; chronic obstructive lung disease; cotton textile workers; occupational health; organic dusts; pulmonary function
Contact
D. Christiani, Harvard School of Public Health, 665 Huntington Avenue, Building 1-1401, Boston, MA 02115 USA
CODEN
EVHPAZ
Publication Date
20101101
Document Type
Journal Article
Email Address
dchris@hsph.harvard.edu
Funding Amount
1348724
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002421
Issue of Publication
11
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
MA; CA
Performing Organization
Harvard University
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