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Health outcomes associated with lung function decline and respiratory symptoms and disease in a community cohort.

Authors
Baughman-P; Marott-JL; Lange-P; Andrew-M; Hnizdo-E
Source
COPD 2011 Apr; 8(2):103-113
NIOSHTIC No.
20038663
Abstract
Background: In workplace respiratory disease prevention, a thorough understanding is needed of the relative contributions of lung function loss and respiratory symptoms in predicting adverse health outcomes. Methods: Copenhagen City Heart Study respiratory data collected at 4 examinations (1976-2003) and morbidity and mortality data were used to investigate these relationships. With 15 or more years of follow-up for a hospital diagnosis of chronic obstructive pulmonary disease (COPD) morbidity, COPD or coronary heart disease (CHD) mortality, and all-cause mortality, risks for these outcomes were estimated in relation to asthma, chronic bronchitis, shortness of breath, and lung function level at examination 2 (1981-1983) or lung function decline established from examinations 1 (1976-1978) to 2 using 4 measures (FEV1 slope, FEV1 relative slope, American College of Occupational and Environmental Medicine's Longitudinal Normal Limit [LNL], or a limit of 90 milliliters per year [ml/yr]). These risks were estimated by hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, height-adjusted baseline forced expiratory volume in 1 second (FEV1/height2), and height. Results: For COPD morbidity, the increasing trend in the HR (95% CI) by quartiles of the FEV1 slope reached a maximum of 3.77 (2.76-5.15) for males, 6.12 (4.63-8.10) for females, and 4.14 (1.57-10.90) for never-smokers. Significant increasing trends were also observed for mortality, with females at higher risk. Conclusion: Lung function decline was associated with increased risk of COPD morbidity and mortality emphasizing the need to monitor lung function change over time in at-risk occupational populations.
Keywords
Respiratory-system-disorders; Pulmonary-function; Lung-disease; Lung-function; Disease-prevention; Workplace-studies; Medical-examinations; Morbidity-rates; Mortality-rates; Chronic-degenerative-diseases; Pulmonary-function-tests; Spirometry; Risk-analysis; Age-factors; Height-factors; Men; Women; Smoking; Medical-monitoring; Surveillance; Author Keywords: Spirometry; Respiratory symptoms; COPD; Mortality; Morbidity
Contact
Penelope Baughman, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Surveillance Branch, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
Publication Date
20110401
Document Type
Journal Article
Email Address
goz2@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1541-2555
NIOSH Division
DRDS
Source Name
COPD: Journal of Chronic Obstructive Pulmonary Disease
State
WV
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