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Nanoindentation measurement of articular cartilage from an in vivo loading model.

Authors
Li-C; King-KB; Pruitt-LA
Source
Trans Annu Meet Orthop Res Soc 2008 Mar; 54:0649
NIOSHTIC No.
20038603
Abstract
Repetitive and forceful hand tasks can give rise to joint pain and induce upper musculoskeletal diseases. Measuring the effects of loading on the mechanical properties of cartilage helps relate exposure to outcome, as well as improve assessment and intervention of disease. Recent efforts have used nanoindentation to measure the local mechanical properties of cartilage in small models such as the rabbit metacarpophalangeal joint (MCP). However, there are challenges to interpreting the measured data, as standardized testing protocols and analysis methods for soft tissue nanoindentation are yet to be established. This work presents an alternative measurement method using nanoindentation, and compares it to the conventional Oliver-Pharr method (O-P) for evaluating the elastic modulus of articular cartilage from an in vivo joint flexion model.
Keywords
Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Musculoskeletal-system-disorders; Biomechanics; Exposure-assessment; Nanotechnology
Publication Date
20080301
Document Type
Conference/Symposia Proceedings
Email Address
cli@newton.berkeley.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007786
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA; CO
Performing Organization
University of California - San Francisco
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