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The effect of frequency and force of in vivo loading on proteoglycan content of rabbit articular cartilage.

Authors
Saadat-E; Majumdar-S; Rempel-DM; King-KB
Source
Trans Annu Meet Orthop Res Soc 2008 Mar; 54:0050
NIOSHTIC No.
20038600
Abstract
Mechanical loading is an important regulator of the metabolic activity of chondrocytes and is essential for maintaining extracellular matrix composition and functional tissue properties. Furthermore, the chondrocyte is very sensitive to frequency and force levels[1-3]. Understanding the effects of frequency and force on chondrocyte metabolism is essential for understanding and treating joint disorders including the development of engineered tissues and of post-traumatic or post-operative rehabilitation protocols. Previous studies have examined these effects on biosynthetic rates of articular cartilage in vitro, but no data is available on the dose response of frequency or force on cartilage metabolism in vivo. We have developed a novel rabbit model of repetitive joint flexion and loading to examine frequency and force in vivo [4]. Using this model, we previously demonstrated an increase in cartilage proteoglycan content with cyclical joint loading of a fixed frequency and force [5]. This study examines the effect of differing levels of frequency and force on the amounts of proteoglycan and collagen in articular cartilage using Fourier Transform Infrared (FTIR) spectroscopic imaging.
Keywords
Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Musculoskeletal-system-disorders; Biomechanics; Force
Publication Date
20080301
Document Type
Conference/Symposia Proceedings
Email Address
Karen.King@UCHSC.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007786
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA; CO
Performing Organization
University of California - San Francisco
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