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Analysis of force-displacement curves of cartilage and biomaterials.

Authors
Li-C; King-KB; Ebenstein-DM; Lin-J; Pruitt-LP
Source
Trans Annu Meet Orthop Res Soc 2007 Feb; 53:1565
NIOSHTIC No.
20038589
Abstract
Nano-mechanical testing equipments have made probing small volumes of sample possible, allowing measurement of local mechanical behavior of complex tissues such as articular cartilage. However, current techniques and theories developed for traditional engineering materials are insufficient for analyzing complex soft biomaterials. A few studies have shown significant adhesive effects in the load-displacement data of compliant polymers such as poly(dimethyl siloxane) (PDMS) using the Johnson-Kendall-Roberts (JKR) adhesion model. It is suspected that indentation of hydrated tissues might have similar adhesive effects. However, no study has addressed this. In this study, an improved measurement protocol is discussed for determining the nano-mechanical properties of cartilage tissues; the issues of adhesion and surface-find are addressed in calculating reliable values of the local tissue modulus which are necessary to study the mechanical function of musculoskeletal tissues. Force-displacement curves of PDMS, agarose gel, and articular cartilage are compared.
Keywords
Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system-disorders; Biomechanics; Nanotechnology
Publication Date
20070201
Document Type
Conference/Symposia Proceedings
Email Address
limeow@gmail.com
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007786
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA; CO
Performing Organization
University of California - San Francisco
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