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Cyclical in vivo loading increases cartilage proteoglycan content in the rabbit metacarpophalangeal joint.

Authors
Saadat-E; Majumdar-S; Burghardt-A; King-KB
Source
Trans Annu Meet Orthop Res Soc 2006 Mar; 52:1352
NIOSHTIC No.
20038588
Abstract
The composition of the extracellular matrix of cartilage dictates its mechanical properties. Proteoglycans (PG) and collagen are two important structural components of the cartilage extracellular matrix. The ability to measure changes both in the amount and distribution of cartilage matrix constituents is essential in understanding early pathological changes of joint diseases. Previous studies have examined the biosynthetic response of articular cartilage with cyclical loading of osteochondral explants in vitro. We have developed a novel method of repetitive joint flexion and loading to examine the biosynthetic response of cyclical loading in vivo. This study examines the change in the amounts of proteoglycans and collagen in articular cartilage resulting from in vivo cyclical loading using Fourier transform infrared (FTIR) imaging spectroscopy.
Keywords
In-vivo-studies; Models; Injuries; Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system-disorders; Biomechanics
Publication Date
20060301
Document Type
Conference/Symposia Proceedings
Email Address
kbking@itsa.ucsf.edu
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007786
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA; CO
Performing Organization
University of California - San Francisco
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