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Nanoindentation of finger joint cartilage in a fluid cell.

Authors
Li-C; Ebenstein-DM; King-K; Pruitt-LA
Source
Trans Annu Meet Orthop Res Soc 2004 Mar; 50:0539
NIOSHTIC No.
20038558
Abstract
Assessing the mechanical properties of diarthrodial joint cartilage is important for the treatment of osteoarthritis and the development of functional tissue-engineered cartilage. The traditional techniques of confined and unconfined compression performed on cartilage plugs and more recent in-situ indentation measurements have shown articular cartilage mechanical properties to be site, depth, and direction-dependent. Further these techniques are limited to larger specimens with relatively smooth joint surfaces. In a preliminary study, nanoindentation performed on rabbit finger joint cartilage has been shown effective in detecting local mechanical properties. Nanoindentation can target the large variety of positions and topographies found in small areas allowing direct assessment of structure-function relationships at the tissue-scale (10-4-10-2 m) and micro-scale (10-7-10-4 m) levels. Such information can provide critical insight into the mechanisms of cartilage function in load support and lubrication, as well as joint degeneration. This study aims to 1) validate the modified nanoindentation technique for mechanical measurements of articular cartilage in a fluid environment and 2) evaluate hydration as a critical testing parameter. In-situ compressive reduced modulus was measured for healthy rabbit metacarpophalangeal (MCP) joint cartilage immersed in saline with a specialized fluid cell tip at fine spatial resolution.
Keywords
Laboratory-animals; Animal-studies; Muscles; Repetitive-work; Cumulative-trauma-disorders; Cumulative-trauma; Musculoskeletal-system-disorders; Biomechanics; Hand-injuries
Publication Date
20040301
Document Type
Conference/Symposia Proceedings
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007786
ISSN
0149-6433
Priority Area
Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
Source Name
Transactions of the Annual Meeting of the Orthopaedic Research Society
State
CA; CO
Performing Organization
University of California - San Francisco
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