Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Mechanical responses to COREXIT® EC9500A in rat trachea in vitro.

Authors
Shimko-MJ; Zaccone-EJ; Thompson-JA; Kashon-ML; Piedimonte-G; Fedan-JS
Source
FASEB J 2011 Apr; 25(Meeting Abstracts):1016.3
NIOSHTIC No.
20038537
Abstract
Oil dispersant COREXIT® EC9500A (CE) was used to reduce the environmental impact of the Deepwater Horizon oil spill in 2010. Little is known of the pulmonary effects of CE on airway smooth muscle and nerves. We investigated in vitro the effects of CE on rat tracheal preparations. In tracheal strips, CE (0.001 %v/v) elicited relaxation. Contraction occurred at higher concentrations (0.003-0.1 %v/v; EC50 0.0031 %v/v). CE (>0.1 %v/v) elicited relaxation of methacholine (MCh; 3x10-5 M)-contracted strips (EC50 0.39 %v/v). CE (0.003 %v/v) had no effect on MCh-induced tone but inhibited neurogenic contractile responses of strips to electrical field stimulation (10 Hz). In the isolated, perfused trachea preparation (IPT), in which agents may be applied separately to the mucosal or serosal surface, CE (0.3-10 %v/v) administered to the mucosal bath resulted in contraction. In MCh-contracted perfused tracheas, mucosal CE (0.1-10 %v/v) elicited contraction followed by relaxation. Thus, CE was less potent in the IPT compared to strips. CE produced a progressive precipitate at >0.1 %v/v. Our results indicate that CE contracts airway smooth muscle and inhibits excitatory neurotransmission. Relaxation at high CE concentrations cannot be distinguished from precipitate formation or osmotic effects.
Keywords
In-vitro-study; Respiratory-system-disorders; Pulmonary-system-disorders; Pulmonary-disorders; Pulmonary-function; Lung-disorders
CODEN
FAJOEC
CAS No.
1338-43-8; 9005-65-6; 9005-70-3; 577-11-7; 29911-28-2; 64742-47-8
Publication Date
20110410
Document Type
Abstract
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISSN
0892-6638
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
The FASEB Journal
State
WV
TOP