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Reduction in surface contamination with antineoplastic drugs in 22 hospital pharmacies in the US following implementation of a closed-system drug transfer device.

Authors
Sessink-PJM; Connor-TH; Jorgenson-JA; Tyler-TG
Source
J Oncol Pharm Pract 2011 Mar; 17(1):39-48
NIOSHTIC No.
20038532
Abstract
Purpose. Surface contamination with the antineoplastic drugs cyclophosphamide, ifosfamide, and 5-fluorouracil was compared in 22 US hospital pharmacies following preparation with standard drug preparation techniques or the PhaSeal® closed-system drug transfer device (CSTD). Methods. Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils, floors in front of BSCs, and counters and analyzed for contamination with cyclophosphamide, ifosfamide, and 5-fluorouracil. Contamination was reassessed several months after the implementation of the CSTD. Surface contamination (ng/cm2) was compared between the two techniques and evaluated with the Signed Rank Test. Results. Using the CSTD compared to the standard preparation techniques, a significant reduction in levels of contamination was observed for all drugs (cyclophosphamide: p < 0.0001; ifosfamide: p < 0.001; 5-fluorouracil: p < 0.01). Median values for surface contamination with cyclophosphamide, ifosfamide, and 5-fluorouracil were reduced by 95%, 90%, and 65%, respectively. Conclusions. Use of the CSTD significantly reduces surface contamination when preparing cyclophosphamide, ifosfamide, and 5-fluorouracil as compared to standard drug preparation techniques.
Keywords
Health-care-facilities; Health-care; Health-care-personnel; Pharmaceuticals; Antineoplastic-agents; Drug-therapy; Drugs; Medicinal-chemicals; Author Keywords: Antineoplastic agents; closed-system drug transfer device; surface contamination; drug preparation; hospital pharmacies; cyclophosphamide
Contact
Dr. Paul J.M. Sessink, Exposure Control B.V., P.O. Box 467, NL-6600AL Wijchen, The Netherlands
CODEN
JOPPFI
CAS No.
50-18-0; 3778-73-2; 51-21-8
Publication Date
20110301
Document Type
Journal Article
Email Address
info@exposurecontrol.nl
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1078-1552
NIOSH Division
DART
Source Name
Journal of Oncology Pharmacy Practice
State
OH; IN; CA
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