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Trends in paraoxonase 1 activity and lifestyle factors in a rural population over time.

Badtke-L; Kelly-KM; Wang-K; Merchant-JA; Ludewig-G
Toxicologist 2011 Mar; 120(Suppl 2):259
Paraoxonase 1 (PON1) is a glycoprotein capable of hydrolyzing many pesticides. There is substantial variation in serum PON1 activity among individuals within a population due to genetic, intrinsic and environmental factors. Low PON1 activity has been associated with increased risk for atherosclerosis and other disorders. It has been shown that PON1 levels appear to be lower in older populations, but no known study has measured serum PON1 activity in the same individuals over time. In a prospective population study ongoing since 1994 and now in its 3rd cycle of data/specimen collection, blood serum and questionnaire data are gathered roughly every 5 years from 499 rural Iowans ages 8-86 at the study onset. Since low PON1 activity increases the risk of pesticide toxicity, we were interested in the effects of lifestyle, diet, occupational exposure and age on PON1 activity. In this pilot study, the 3 serum samples from 31 females and 30 males were evaluated for PON1 activity using phenyl acetate and CMPA [4-(Chloromethyl)phenyl acetate] as substrates. Mixed model analyses (alpha = .05) did not significantly show the expected decrease in serum PON1 activity over time with either substrate. Body Mass Index, gender, location (farm/rural/town), and systolic and diastolic blood pressure did not significantly influence substrate levels, though gender, BMI and location showed a marginal influence. This population also demonstrated no significant changes in these factors over this 10-year span. This pilot study did not conclusively confirm the assumed age-related decrease in PON1 levels or changes in these lifestyle and health parameters. Increasing the number of participants and including more questionnaire data will allow us to identify risk factors for low PON1 status and allow us to counsel at-risk subpopulations about their individual pesticide vulnerability.
Age-factors; Biological-effects; Cellular-reactions; Environmental-exposure; Exposure-assessment; Exposure-methods; Immune-system; Inhalation-studies; Medical-research; Pesticides-and-agricultural-chemicals; Questionnaires; Risk-analysis; Risk-factors; Statistical-analysis
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Cooperative Agreement
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Source Name
The Toxicologist. Society of Toxicology 50th Annual Meeting and ToxExpo, March 6-10, 2011, Washington, DC
Performing Organization
University of Iowa, Iowa City, Iowa