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Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity.

Authors
Antonini-JM; Keane-M; Chen-BT; Stone-S; Roberts-JR; Schwegler-Berry-D; Andrews-RN; Frazer-DG; Sriram-K
Source
Nanotoxicology 2011 Dec; 5(4):700-710
NIOSHTIC No.
20038340
Abstract
The goal was to determine if increasing welding voltage changes the physico-chemical properties of the fume and influences lung responses. Rats inhaled 40 mg/m3 (3 h/day x 3 days) of stainless steel (SS) welding fume generated at a standard voltage setting of 25 V (regular SS) or at a higher voltage (high voltage SS) of 30 V. Particle morphology, size and composition were characterized. Bronchoalveolar lavage was performed at different times after exposures to assess lung injury. Fumes collected from either of the welding conditions appeared as chain-like agglomerates of nanometer-sized primary particles. High voltage SS welding produced a greater number of ultrafine-sized particles. Fume generated by high voltage SS welding was higher in manganese. Pulmonary toxicity was more substantial and persisted longer after exposure to the regular SS fume. In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile.
Keywords
Nanotechnology; Toxic-vapors; Welders; Welders-lung; Welding; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Fumes; Animal-studies; Stainless-steel; Lung-burden; Particulates; Exposure-assessment; Manganese-compounds; Author Keywords: Welding fume; inhalation; lung burden; nanoparticles; pulmonary toxicity
Contact
Dr. James M. Antonini, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
CAS No.
7439-96-5
Publication Date
20111201
Document Type
Journal Article
Fiscal Year
2012
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1743-5390
NIOSH Division
HELD; DART
Priority Area
Manufacturing
Source Name
Nanotoxicology
State
WV; OH
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