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Risk factors for oligodendroglial tumors: a pooled international study.

Authors
McCarthy-BJ; Rankin-KM; Aldape-K; Bondy-ML; Brännström-T; Broholm-H; Feychting-M; Il'yasova-D; Inskip-PD; Johansen-C; Melin-BS; Ruder-AM; Butler-MA; Scheurer-ME; Schüz-J; Schwartzbaum-JA; Wrensch-MR; Davis-FG
Source
Neuro-Oncology 2011 Feb; 13(2):242-250
NIOSHTIC No.
20038262
Abstract
Oligodendroglial tumors are rare subtypes of brain tumors and are often combined with other glial tumors in epidemiological analyses. However, different demographic associations and clinical characteristics suggest potentially different risk factors. The purpose of this study was to investigate possible risk factors for oligodendroglial tumors (including oligodendroglioma, anaplastic oligodendroglioma, and mixed glioma). Data from 7 case-control studies (5 US and 2 Scandinavian) were pooled. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for age group, gender, and study site. Data on 617 cases and 1260 controls were available for analyses. Using data from all 7 studies, history of allergies and/or asthma was associated with a decreased risk of anaplastic oligodendroglioma (OR = 0.6; 95% CI: 0.4-0.9), and history of asthma only was associated with a decreased risk of oligodendroglioma (OR = 0.5; 95% CI: 0.3-0.9) and anaplastic oligodendroglioma (OR = 0.3; 95% CI: 0.1-0.9). A family history of brain tumors was associated with an increased risk of anaplastic oligodendroglioma (OR = 2.2; 95% CI: 1.1-4.5). Having had chicken pox was associated with a decreased risk of oligodendroglioma (OR = 0.6; 95% CI: 0.4-0.9) and anaplastic oligodendroglioma (OR = 0.5; 95% CI: 0.3-0.9) in the US studies. Although there is some overlap in risk factors between oligodendroglial tumors and gliomas as a group, it is likely that additional factors specific to oligodendroglial tumors have yet to be identified. Large, multi-institution international studies will be necessary to better characterize these etiological risk factors.
Keywords
Cancer; Brain-disorders; Central-nervous-system-disorders; Tumors; Epidemiology; Statistical-analysis; Risk-analysis; Author Keywords: anaplastic oligodendroglioma; epidemiology; mixed gliomaoligodendroglioma; risk factors
Contact
Bridget J. McCarthy, PhD, Department of Epidemiology/Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St. (M/C 923), Chicago, IL 60612
CODEN
NEURJR
Publication Date
20110201
Document Type
Journal Article
Email Address
bjm3@uic.edu
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1522-8517
NIOSH Division
DSHEFS; DART
Priority Area
Agriculture, Forestry and Fishing; Services
Source Name
Neuro-Oncology
State
OH; IL; TX; NC; MD; CA
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