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Pulmonary alveolar proteinosis in workers at an indium processing facility -author's reply.

Authors
Cummings-KJ; Kreiss-K; Roggli-VL
Source
Am J Respir Crit Care Med 2010 Aug; 182(4):578-579
NIOSHTIC No.
20038222
Abstract
Drs. Lison and Delos describe a reexamination of lung sections of rats exposed to indium-tin oxide (ITO). They report that the proteinaceous material noted in the alveolar lumen (1) was PAS-positive, consistent with pulmonary alveolar proteinosis. We agree with them that this new observation provides additional support for our assertion that ITO caused pulmonary alveolar proteinosis in the cases we described (2). Drs. Lison and Delos question the suggestion of an autoimmune mechanism for indium-related pulmonary alveolar proteinosis. We would like to address their comments on this issue.
Keywords
Tin-oxides; Alveolar-cells; Respiratory-system-disorders; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Airborne-dusts; Antibody-response; Autoimmunity; Immune-reaction; Protein-biochemistry; Proteins; Tissue-disorders; Lung-tissue; Lung-disorders
CODEN
AJCMED
CAS No.
71243-84-0
Publication Date
20100815
Document Type
Other
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1073-449X
NIOSH Division
DRDS
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV; NC
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