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Persistence of tungsten oxide particle/fiber mixtures in artificial human lung fluids.

Authors
Stefaniak-AB
Source
Part Fibre Toxicol 2010 Dec; 7:38
NIOSHTIC No.
20038152
Abstract
Background: During the manufacture of tungsten metal for non-sag wire, tungsten oxide powders are produced as intermediates and can be in the form of tungsten trioxide (WO3) or tungsten blue oxides (TBOs). TBOs contain fiber-shaped tungsten sub-oxide particles of respirable or thoracic size. The aim of this research was to investigate whether fiber-containing TBOs had prolonged biodurability in artificial lung fluids compared to tungsten metal or WO3 and therefore potentially could pose a greater inhalation hazard. Methods: Dissolution of tungsten metal, WO3, one fiber-free TBO (WO2.98), and three fiber-containing TBO (WO2.81, WO2.66, and WO2.51) powders were measured for the material as-received, dispersed, and mixed with metallic cobalt. Solubility was evaluated using artificial airway epithelial lining fluid (SUF) and macrophage phagolysosomal simulant fluid (PSF). Results: Dissolution rates of tungsten compounds were one to four orders of magnitude slower in PSF compared to SUF. The state of the fiber-containing TBOs did not influence their dissolution in either SUF or PSF. In SUF, fiber-containing WO2.66 and WO2.51 dissolved more slowly than tungsten metal or WO3. In PSF, all three fiber-containing TBOs dissolved more slowly than tungsten metal. Conclusions: Fiber-containing TBO powders dissolved more slowly than tungsten metal and WO3 powders in SUF and more slowly than tungsten metal in PSF. Existing pulmonary toxicological information on tungsten compounds indicates potential for pulmonary irritation and possibly fibrosis. Additional research is needed to fully understand the hazard potential of TBOs.
Keywords
Respiratory-system-disorders; Respirable-dust; Tungsten-compounds; Lung-function; Lung-irritants; Heavy-metals; Fiber-deposition; Inhalants; Pulmonary-function; Pulmonary-disorders
Contact
Aleksandr B Stefaniak, National Institute for Occupational Safety and Health, DRDS, 1095 Willowdale Road, Morgantown, WV 26505 USA
CAS No.
7440-33-7
Publication Date
20101206
Document Type
Journal Article
Email Address
AStefaniak@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
ISSN
1743-8977
NIOSH Division
DRDS
Priority Area
Manufacturing
Source Name
Particle and Fibre Toxicology
State
WV
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