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Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats.

Authors
Ma-JY; Zhao-H; Mercer-RR; Barger-M; Rao-M; Meighan-T; Schwegler-Berry-D; Castranova-V; Ma-JK
Source
Nanotechnology 2011 Sep; 5(3):312-325
NIOSHTIC No.
20038116
Abstract
The use of cerium compounds as diesel fuel catalyst results in the emission of cerium oxide nanoparticles (CeO2) in the exhaust. This study characterized the potential effects of CeO2 exposure on lung toxicity. Male Sprague Dawley rats were exposed to CeO2 by a single intratracheal instillation at 0.15, 0.5, 1, 3.5 or 7 mg/kg body weight. At 1 day after exposure, CeO2 significantly reduced NO production, but increased IL-12 production, by alveolar macrophages (AM) in response to ex vivo lipopolysacchride (LPS) challenge, and caused AMapoptosis, through activation of caspases 9 and 3. CeO2 exposure markedly increased suppressor of cytokine signaling-1 at 1-day and elevated arginase-1 at 28-day post exposure in lung cells, while osteopontin was significantly elevated in lung tissue at both time points. CeO2 induced inflammation, cytotoxicity, air/blood barrier damage, and phospholipidosis with enlarged AM. Thus, CeO2 induced lung inflammation and injury in lungs which may lead to fibrosis.
Keywords
Nanotechnology; Diesel-emissions; Diesel-exhausts; Respiratory-irritants; Pulmonary-function; Pulmonary-system; Lung-irritants; Animal-studies; Laboratory-animals; Exposure-assessment; Alveolar-cells; Polysaccharides; Genotoxic-effects; Lung-cells; Cytotoxic-effects; Phospholipids; Lung-disorders; Lung-fibrosis; Pulmonary-system-disorders; Nitrogen-oxides; Cerium-compounds; Author Keywords: Cerium oxide; nanoparticle; lung injury; alveolar macrophages; pulmonary fibrosis
Contact
Dr Jane Y. C.Ma, PhD, PPRB/HELD, NIOSH, 1095Willowdale Road, Morgantown, West Virginia 26505-2888, USA
CODEN
NNOTER
CAS No.
1306-38-3
Publication Date
20110901
Document Type
Journal Article
Email Address
jym1@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0957-4484
NIOSH Division
HELD
Priority Area
Transportation, Warehousing and Utilities
Source Name
Nanotechnology
State
WV
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