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Fenton activity and cytotoxicity studies of iron-loaded carbon particles.

Authors
Peebles-B; Nagy-A; Waldman-WJ; Dutta-PK
Source
Environ Sci Technol 2010 Sep; 44(17):6887-6892
NIOSHTIC No.
20038097
Abstract
The chemical and biological properties of iron-loaded manufactured carbon nanoparticles (Flammruss 101) were contrasted with those of an iron-loaded synthetic carbon particle. X-ray photoelectron spectroscopy was used to characterize the iron on the carbon particles. Production of hydroxyl free radicals via the Fenton reaction was monitored by electron paramagnetic resonance spectroscopy. The iron-loaded synthetic carbon particles produced a positive Fenton response, whereas the iron-loaded manufactured carbon particles did not. The source of the Fenton activity of the synthetic carbon particles is proposed to be a soluble iron compound that was formed during the synthesis of the particle. A likely candidate for the soluble iron species is Fe2F5, which was synthesized and its properties were examined. Higher toxicity of Fe2F5 toward murine macrophages compared with other simple iron salts was attributed to soluble iron that was stabilized by the fluoride ligand. The cytotoxicity of manufactured carbon particles toward murine macrophages decreased or remained unaltered upon impregnation with iron compounds.
Keywords
Aerosol-particles; Biological-effects; Biological-material; Carbonates; Chemical-properties; Chemical-synthesis; Cytotoxic-effects; Fluorescence-spectrometry; Iron-compounds; Nanotechnology; Particulates; Photochemical-reactions; Spectrographic-analysis
Contact
Prabir K. Dutta, Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210
CODEN
ESTHAG
Publication Date
20100901
Document Type
Journal Article
Email Address
dutta.1@osu.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-009141
Issue of Publication
17
ISSN
0013-936X
Source Name
Environmental Science and Technology
State
OH; TX
Performing Organization
The Ohio State University
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