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Cumulative lead exposure and age-related hearing loss: the VA Normative Aging Study.

Authors
Park-SK; Elmarsafawy-S; Mukherjee-B; Spiro-A III; Vokonas-PS; Nie-H; Weisskopf-MG; Schwartz-J; Hu-H
Source
Hear Res 2010 Oct; 269(1-2):48-55
NIOSHTIC No.
20038087
Abstract
Although lead has been associated with hearing loss in occupational settings and in children, little epidemiologic research has been conducted on the impact of cumulative lead exposure on age-related hearing loss in the general population. We determined whether bone lead levels, a marker of cumulative lead exposure, are associated with decreased hearing ability in 448 men from the Normative Aging Study, seen between 1962 and 1996 (2264 total observations). Air conduction hearing thresholds were measured at 0.25-8 kHz and pure-tone averages (PTA) (mean of 0.5, 1, 2 and 4 kHz) were computed. Tibia and patella lead levels were measured using K X-ray fluorescence between 1991 and 1996. In cross-sectional analyses, after adjusting for potential confounders including occupational noise, patella lead levels were significantly associated with poorer hearing thresholds at 2, 3, 4, 6 and 8 kHz and PTA. The odds of hearing loss significantly increased with patella lead levels. We also found significant positive associations between tibia lead and the rate change in hearing thresholds at 1, 2, and 8 kHz and PTA in longitudinal analyses. Our results suggest that chronic low-level lead exposure may be an important risk factor for age-related hearing loss and reduction of lead exposure could help prevent or delay development of age-related hearing loss.
Keywords
Hearing-loss; Age-factors; Lead-absorption; Lead-compounds; Epidemiology; Exposure-assessment; Biomarkers; X-ray-fluorescence-analysis; Risk-factors; Bone-disorders; Hearing-threshold
Contact
Sung Kyun Park, Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
CODEN
HERED3
CAS No.
7439-92-1
Publication Date
20101001
Document Type
Journal Article
Email Address
sungkyun@umich.edu
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008455
Issue of Publication
1-2
ISSN
0378-5955
Source Name
Hearing Research
State
MI; MA; IN
Performing Organization
University of Michigan, Ann Arbor
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