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Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes.

Authors
Theppeang-K; Schwartz-BS; Lee-BK; Lustberg-ME; Silbergeld-EK; Kelsey-KT; Parsons-PJ; Todd-AC
Source
J Occup Environ Med 2004 Jun; 46(6):528-537
NIOSHTIC No.
20038079
Abstract
A cross-sectional analysis was performed to evaluate associations of polymorphisms in the vitamin D receptor (VDR), delta-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea. There was a wide range of patella lead (from below detection limit to 946 microg Pb/g bone mineral), with a mean (standard deviation) of 75.2 (101.0). There were no associations of ALAD or eNOS genotypes with patella lead, but workers with the VDR B allele had significantly (P value < 0.05) higher patella lead (on average, 25% or approximately 6.6 microg Pb/g bone mineral) than lead workers with the VDR bb genotype. There was evidence that the relation between age and patella lead was modified by both the VDR and eNOS genotypes.
Keywords
Lead-absorption; Humans; Exposure-levels; Exposure-limits; Occupational-hazards; Occupational-health; Workers; Blood-analysis; Blood-cells; Biomarkers; Age-factors; Bone-structure; Humans; Men; Women
Contact
Andrew C. Todd, PhD, The Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029
CODEN
JOEMFM
CAS No.
7439-92-1
Publication Date
20040601
Document Type
Journal Article
Email Address
andrew.todd@mssm.edu
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
6
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
MA; MD; NY
Performing Organization
Johns Hopkins University
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