Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China.

Authors
Stolzenberg-Solomon-RZ; Qiao-YL; Abnet-CC; Ratnasinghe-DL; Dawsey-SM; Dong-ZW; Taylor-PR; Mark-SD
Source
Cancer Epidemiol Biomark Prev 2003 Nov; 12(11)(PT 1):1222-1226
NIOSHTIC No.
20038067
Abstract
Linxian, a rural county in North Central China, has among the highest rates of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in the world. Its inhabitants have documented chronic nutritional inadequacies, including folate and vitamin B(12) deficiencies. Using a cohort we have been studying in Linxian since 1985, we examined the relationship between incident ESCC and GCA cancers and three polymorphisms in two genes that code for enzymes that require folate and B(12) as cofactors: methionine synthase reductase (MTRR) A66G and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C. We conducted a case-cohort study among 4005 individuals in our cohort who were alive and cancer free in 1991 and had blood samples adequate for DNA extraction. Polymorphisms were measured on all 219 incident cancers (129 ESCCs and 90 GCAs) that developed through May 1996 and on 398 controls. Cox proportional hazard models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). Individuals with the MTHFR 677TT genotype had significantly higher combined ESCC/GCA risks (RR, 1.45; 95% CI, 1.02-2.05) than those with CC or CT genotypes. The only subjects to have MTHFR 1298CC were three ESCC cases (P = 0.03). Compared with subjects with the MTRR 66AA genotype, subjects with the AG or GG genotypes had significantly higher risk of ESCC (RR, 1.59; 95% CI, 1.04-2.42). No association was observed for GCA. Our results suggest that the MTHFR C677T and MTRR A66G polymorphisms influence the risk of ESCC and GCA in this population.
Keywords
Adrenal-gland-disorders; Cancer; Carcinomas; Bacteria; Etiology; Pathology; Humans; Men; Women; Age-groups; Proteins; Risk-factors; Genetics
Contact
Rachael Z. Stolzenberg-Solomon, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Suite 320 MSC 7232, Rockville, Maryland 20852
CODEN
CEBPE4
Publication Date
20021101
Document Type
Journal Article
Email Address
rs22lz@nih.gov
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
11
ISSN
1055-9965
Source Name
Cancer Epidemiology, Biomarkers & Prevention
State
MD
Performing Organization
Johns Hopkins University
TOP