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Toxicity of dusts collected from South African mines: free-radical production and lipid peroxidation.

Authors
Vetten-M; Vallyathan-V; Leonard-SS; Kenyon-A; Gulumian-M
Source
Toxicol Lett 2010 Jul; 196(Suppl 1):S70-S71
NIOSHTIC No.
20038041
Abstract
Occupational exposure to mine dust can damage lung tissue and cause respiratory diseases. In this study, dusts from five South African mines were collected and their toxicities assessed. The samples were obtained from various workplaces within the mines. Electron spin resonance was performed to evaluate the ability of the samples to produce hydroxyl radicals in the presence of hydrogen peroxide. From these initial experiments, six samples were selected for further studies. The samples were incubated with a bronchial epithelial cell line to determine levels of hydroxyl radicals produced by the cells in response to the dust. In addition, levels of lipid peroxidation, as determined by the 8-isoprostane concentration in cell culture media, were measured. These experiments showed variations in the generation of free radicals between samples from the different mines and within the mines themselves. Levels of 8-isoprostane also varied between samples. This data indicates differences in toxicity of the various dust samples, warranting further investigations to correlate the composition and characteristics of the samples to their toxicity.
Keywords
Dust-exposure; Dust-particles; Exposure-assessment; Mining-industry; Toxic-materials; Toxicology; Dusts; In-vitro-studies
CODEN
TOLED5
Publication Date
20100717
Document Type
Abstract
Fiscal Year
2010
NTIS Accession No.
NTIS Price
ISSN
0378-4274
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Toxicology Letters. Abstracts of the XII International Congress of Toxicology
State
WV
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