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High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots.

Authors
Yong-LC; Petersen-MR
Source
Br J Nutr 2011 Feb; 105(4):496-505
NIOSHTIC No.
20037971
Abstract
Experimental studies suggest that B vitamins such as niacin, folate, riboflavin, vitamin B6 and vitamin B12 may protect against DNA damage induced by ionising radiation (IR). However, to date, data from IR-exposed human populations are not available. We examined the intakes of these B vitamins and their food sources in relation to the frequency of chromosome translocations as a biomarker of cumulative DNA damage, in eighty-two male airline pilots. Dietary intakes were estimated by using a self-administered semi-quantitative FFQ. Translocations in peripheral blood lymphocytes were scored by using fluorescence in situ hybridisation whole-chromosome painting. Negative binomial regression was used to estimate rate ratios and 95 % CI, adjusted for age and occupational and lifestyle factors. We observed a significant inverse association between translocation frequency and dietary intake of niacin (P = 002): adjusted rate ratio for subjects in the highest tertile compared with the lowest tertile was 058 (95 % CI 040, 083). Translocation frequency was not associated with total niacin intake from food and supplements as well as dietary or total intake of folate, riboflavin or vitamin B6 or B12. However, the adjusted rate ratios were significant for subjects with = median compared with < median intake of whole grains (P = 003) and red and processed meat (P = 001): 069 (95 % CI 050, 096) and 156 (95 % CI 113, 216), respectively. Our data suggest that a high intake of niacin from food or a diet high in whole grains but low in red and processed meat may protect against cumulative DNA damage in IR-exposed persons.
Keywords
Pilots; Vitamins; Food; Men; Age-groups; Biomarkers; Dietary-effects; Aircrews; Author Keywords: Niacin; Vitamin B; Chromosome translocations; Airline pilots; Radiation exposure
Contact
Dr. L. C. Yong, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-15, Cincinnati OH 45226
CODEN
BJNUAV
Publication Date
20110201
Document Type
Journal Article
Email Address
lay7@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0007-1145
NIOSH Division
DSHEFS
Priority Area
Transportation, Warehousing and Utilities
Source Name
British Journal of Nutrition
State
OH
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