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Use of anthrax vaccine in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009.

Authors
Gordon Wright-J; Quinn-CP; Shadomy-S; Messonnier-N; Advisory Committee on Immunization Practices; ACIP Anthrax Vaccine Working Group
Source
MMWR Recomm Rep 2010 Jul; 59(RR-06):1-30
NIOSHTIC No.
20037839
Abstract
These recommendations from the Advisory Committee on Immunization Practices (ACIP) update the previous recommendations for anthrax vaccine adsorbed (AVA) (CDC. Use of anthrax vaccine in the United States: Recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2000;49:1--20; CDC. Use of anthrax vaccine in response to terrorism: supplemental recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2002;51:1024--6) and reflect the status of anthrax vaccine supplies in the United States. This statement 1) provides updated information on anthrax epidemiology; 2) summarizes the evidence regarding the effectiveness and efficacy, immunogenicity, and safety of AVA; 3) provides recommendations for pre-event and preexposure use of AVA; and 4) provides recommendations for postexposure use of AVA. In certain instances, recommendations that did not change were clarified. No new licensed anthrax vaccines are presented. Substantial changes to these recommendations include the following: 1) reducing the number of doses required to complete the pre-event and preexposure primary series from 6 doses to 5 doses, 2) recommending intramuscular rather than subcutaneous AVA administration for preexposure use, 3) recommending AVA as a component of postexposure prophylaxis in pregnant women exposed to aerosolized Bacillus anthracis spores, 4) providing guidance regarding preexposure vaccination of emergency and other responder organizations under the direction of an occupational health program, and 5) recommending 60 days of antimicrobial prophylaxis in conjunction with 3 doses of AVA for optimal protection of previously unvaccinated persons after exposure to aerosolized B. anthracis spores.
Keywords
Vaccines; Biological-warfare-agents; Biological-weapons; Infectious-diseases; Microorganisms; Bacterial-disease; Bacteria; Bacterial-infections; Epidemiology
Contact
Jennifer Gordon Wright, DVM, CDC, 1600 Clifton Road, NE; MS A-38; Atlanta, GA 30333
Publication Date
20100723
Document Type
Journal Article
Email Address
jgwright@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
RR-06
ISSN
1057-5987
NIOSH Division
EPRO
Source Name
Morbidity and Mortality Weekly Report: Recommendations and Report
State
GA
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