Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers.
Connor-TH; DeBord-DG; Pretty-JR; Oliver-MS; Roth-TS; Lees-PSJ; Krieg-EF Jr.; Rogers-B; Escalante-CP; Toennis-CA; Clark-JC; Johnson-BC; McDiarmid-MA
J Occup Environ Med 2010 Oct; 52(10):1019-1027
Objective: This study evaluated health care worker exposure to antineoplastic drugs. Methods: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Results: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Conclusions: Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.
Biological-factors; Biological-monitoring; Biological-systems; Biological-transport; Biomarkers; Cancer-rates; Carcinogenesis; Carcinogenicity; Carcinogens; Chemical-hypersensitivity; Drugs; Epidemiology; Exposure-assessment; Exposure-levels; Physiological-effects; Physiological-factors; Physiological-response; Reproductive-hazards; Reproductive-system-disorders; Risk-analysis; Risk-factors; Safety-measures; Statistical-analysis; Teratogenesis; Teratogens; Work-analysis; Work-areas; Work-environment; Worker-health; Work-operations; Work-performance; Workplace-studies; Work-practices
Thomas H. Connor, National Institute for Occupational Safety and Health, DART, Centers for Disease Control and Prevention, MS C-23,4676 Columbia Pkwy, Cincinnati, OH 45226
Journal of Occupational and Environmental Medicine