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Matrix metalloproteinases, IL-8 and glutathione in the prognosis of workers exposed to chlorine.

Authors
Maghni-K; Malo-JL; L'Archevêque-J; Castellanos-L; Gautrin-D
Source
Allergy 2010 Jun; 65(6):722-730
NIOSHTIC No.
20037761
Abstract
BACKGROUND: Workers exposed to chlorine may be at risk of deterioration in FEV1. METHODS: A prospective study of 72 workers examined over a 5.8 +/- 1.9 year period. A sample of induced sputum for cells and mediators was obtained in 69 subjects at baseline (Vb) and in 36 both at Vb and at follow-up (Vf). RESULTS: Sixty-four workers (89%) experienced at least one accidental inhalation of chlorine in the interval. The mean decrease in FEV1 was 30 ml/year and thus was within normal limits. Among the analysed remodelling markers, the level of the MMP-9-TIMP-1 complex, but not of free MMP-9 and TIMP-1, significantly diminished from Vb to Vf. We found significant correlations between neutrophils, IL-8, MMP-9 and MMP9-TIMP-1 complex at Vb and Vf. While levels of total glutathione, IL-8, MMP9, TIMP-1 and MMP9-TIMP-1 complex were highly correlated with each other at Vb, this was inconstant at Vf. Levels of MMP9-TIMP1 complex and of TIMP1 at Vf were significantly lower in workers reporting chlorine puffs with mild acute respiratory symptoms between visits compared to those who had no, or asymptomatic inhalations (P = 0.03 and 0.02, respectively). The fall in FEV1 from Vb to Vf was significantly correlated with levels of glutathione at Vb. Cough between visits was associated with a decrease in FEV1 (P = 0.06). CONCLUSION: Although no accelerated loss in FEV1 was documented in these workers exposed to chlorine, subjects with a greater fall in FEV1 were more likely to report cough and have higher levels of total glutathione at Vb.
Keywords
Accident-rates; Accident-statistics; Airway-obstruction; Chemical-hypersensitivity; Chlorine-compounds; Dose-response; Exposure-assessment; Exposure-levels; Exposure-methods; Inhalation-studies; Occupational-exposure; Occupational-hazards; Occupational-health; Pulmonary-system-disorders; Respiratory-function-tests; Respiratory-hypersensitivity; Respiratory-irritants; Statistical-analysis; Author Keywords: irritant-induced asthma; occupational asthma; reactive airways dysfunction syndrome
Contact
Jean-Luc Malo, MD, Department of Chest Medicine, Hospital du Sacre-Coeur, 5400 West Gouin Blvd, Montreal, QC, Canada H4J 1C5
CODEN
LLRGDY
CAS No.
7782-50-5; 70-18-8
Publication Date
20100601
Document Type
Journal Article
Funding Amount
375000
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004058
Issue of Publication
6
ISSN
0105-4538
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Allergy
Performing Organization
Hospital du Sacre-Coeur, Montreal, Quebec
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