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The occupational contribution to severe exacerbation of asthma.

Authors
Henneberger-PK; Mirabelli-MC; Kogevinas-M; Antó-JM; Plana-E; Dahlman-Höglund-A; Jarvis-DL; Kromhout-H; Lillienberg-L; Norbäck-D; Olivieri-M; Radon-K; Torén-K; Urrutia-I; Villani-S; Zock-JP
Source
Eur Respir J 2010 Oct; 36(4):743-750
NIOSHTIC No.
20037755
Abstract
The goal of this study was to identify occupational risk factors for severe exacerbation of asthma and estimate the extent to which occupation contributes to these events. The 966 participants were working adults with current asthma who participated in the follow-up phase of the European Community Respiratory Health Survey. Severe exacerbation of asthma was defined as self-reported unplanned care for asthma in the past 12 months. Occupations held in the same period were combined with a general population job-exposure matrix to assess occupational exposures. 74 participants reported having had at least one severe exacerbation event, for a 1-yr cumulative incidence of 7.7%. From regression models that controlled for confounders, the relative risk (RR) was statistically significant for low (RR 1.7, 95% CI 1.1-2.6) and high (RR 3.6, 95% CI 2.2-5.8) biological dust exposure, high mineral dust exposure (RR 1.8, 95% CI 1.02-3.2), and high gas and fumes exposure (RR 2.5, 95% CI 1.2-5.5). The summary category of high dust, gas, or fumes exposure had RR 3.1 (95% CI 1.9-5.1). Based on this RR, the population attributable risk was 14.7% among workers with current asthma. These results suggest occupation contributes to approximately one in seven cases of severe exacerbation of asthma in a working population, and various agents play a role.
Keywords
Respiratory-hypersensitivity; Respiratory-system-disorders; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Inhalants; Particulates; Fumes; Exposure-limits; Bronchial-asthma; Author Keywords: Asthma; Exacerbation; Occupational; Work-related
Contact
P.K. Henneberger, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS H2800, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
ERJOEI
Publication Date
20101001
Document Type
Journal Article
Email Address
pkh0@cdc.gov
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0903-1936
NIOSH Division
DRDS
Source Name
European Respiratory Journal
State
WV
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