Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead.

Authors
Shih-RA; Hu-H; Weisskopf-MG; Schwartz-BS
Source
Environ Health Perspect 2007 Mar; 115(3):483-492
NIOSHTIC No.
20037719
Abstract
OBJECTIVE: We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. DATA SOURCES: A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. DATA EXTRACTION: Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. CONCLUSIONS: At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults.
Keywords
Lead-poisoning; Lead-absorption; Humans; Men; Women; Environmental-exposure; Occupational-exposure; Blood-samples; Author Keywords: adults; blood; bone; cognitive function; lead; neurobehavior
Contact
B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St., Rm. W7041, Baltimore, Maryland 21205 USA
CODEN
EVHPAZ
Publication Date
20070301
Document Type
Journal Article
Email Address
bschwart@jhsph.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
3
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
MA; MD
Performing Organization
Johns Hopkins University
TOP