Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Lead and cognitive function in adults: a questions and answers approach to a review of the evidence for cause, treatment, and prevention.

Authors
Schwartz-BS; Stewart-WF
Source
Int Rev Psychiatry 2007 Dec; 19(6):671-692
NIOSHTIC No.
20037696
Abstract
Lead has been extensively used worldwide in gasoline, consumer products, commercial applications, and industrial settings. Its use in gasoline and paint has been particularly hazardous to public health leading to widespread population exposure and substantial lifetime cumulative doses in most Americans over age 40 years. Cumulative lead dose can be estimated by measuring the current concentration of lead in tibia bone by X-ray fluorescence. A growing literature has documented that tibia lead levels are associated with decrements in cognitive function and declines in cognitive function over time. Furthermore, there are several interesting lines of biochemical and epidemiological investigation that have demonstrated potential links of lead to neurodegenerative diseases. These studies support the inference that a proportion of what has been termed 'normal' age-related cognitive decline may, in fact, be due to exposure to neurotoxicants such as lead. Well-designed studies of cumulative lead dose and Alzheimer's disease risk should be conducted to follow-up on these leads. The strong and compelling body of literature on lead and cognitive dysfunction and decline also supports a need for intervention studies to prevent lead-related cognitive decline.
Keywords
Lead-poisoning; Neurological-diseases; Neurological-system; Environmental-exposure; Exposure-levels; Biomarkers; Epidemiology
Contact
Brian S. Schwartz, Johns Hopkins Bloomberg School of Public Health, Room W7041, 615 North Wolfe Street, Baltimore, MD 21215, USA
CODEN
IRPSE2
CAS No.
7439-92-1
Publication Date
20071201
Document Type
Journal Article
Email Address
bschwart@jhsph.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
6
ISSN
0954-0261
Source Name
International Review of Psychiatry
State
MD
Performing Organization
Johns Hopkins University
TOP