Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Environmental lead exposure and cognitive function in community-dwelling older adults.

Authors
Shih-RA; Glass-TA; Bandeen-Roche-K; Carlson-MC; Bolla-KI; Todd-AC; Schwartz-BS
Source
Neurology 2006 Nov; 67(9):1556-1562
NIOSHTIC No.
20037676
Abstract
OBJECTIVE: To determine if long-term exposure to high levels of lead in the environment is associated with decrements in cognitive ability in older Americans. METHODS: We completed a cross-sectional analysis using multiple linear regression to evaluate associations of recent (in blood) and cumulative (in tibia) lead dose with cognitive function in 991 sociodemographically diverse, community-dwelling adults, aged 50 to 70 years, randomly selected from 65 contiguous neighborhoods in Baltimore, MD. Tibia lead was measured with (109)Cd induced K-shell X-ray fluorescence. Seven summary measures of cognitive function were created based on standard tests in these domains: language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, visual memory, and visuoconstruction. RESULTS: The mean (SD) blood lead level was 3.5 (2.2) microg/dL and tibia lead level was 18.7 (11.2) microg/g. Higher tibia lead levels were consistently associated with worse cognitive function in all seven domains after adjusting for age, sex, APOE-epsilon4, and testing technician (six domains p
Keywords
Environmental-exposure; Exposure-levels; Age-groups; Humans; Men; Women; Lead-absorption; Lead-poisoning; Analytical-methods; Blood-analysis; Blood-samples; Nervous-system; Neurological-system; Epidemiology; Statistical-analysis; Demographic-characteristics
Contact
Dr. Brian S. Schwartz, Division of Occupational and Environmental Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7041, Baltimore, MD 21205
CODEN
NEURAI
CAS No.
7439-92-1
Publication Date
20061114
Document Type
Journal Article
Email Address
bschwart@jhsph.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
9
ISSN
0028-3878
Source Name
Neurology
State
MD; NY
Performing Organization
Johns Hopkins University
TOP