Fantastic voyage and opportunities of engineered nanomaterials: what are the potential risks of occupational exposures?
Kagan-VE; Shi-J; Feng-W; Shvedova-AA; Bengt-F
J Occup Environ Med 2010 Sep; 52(9):943-946
Insufficiency and ambiguity of the existing in vitro and particularly the in vivo toxicological data are hampering the risk assessment process required for scientifically sound regulatory and policy decisionmaking. Standardization of methods and reference materials are therefore a priority when conducting nanotoxicity testing. Furthermore, one should not confuse hazard data from toxicity studies with the concept of health risk: it must be remembered that exposure assessment is also an integral part of the equation. More work is needed to develop appropriate methodologies with which to monitor nanoparticle exposure in the workplace and in the natural environment. Finally, one should take care not to generalize when reporting on potential adverse health effects of "nanoparticles," unless such generalizations are justified. The terms "nanoparticle" and "nanomaterial" are very broad (in principal, any material of any composition with one or more dimensions in the submicrometer range) and even a single class of nanomaterials, such as carbon nanotubes, can be subdivided into numerous categories with unique properties, based on physicochemical parameters such as size, charge, surface modification, etc. Material characterization is thus a critical component of understanding nanomaterial- related risk to human health.
Analytical-processes; Biological-effects; Cell-biology; Environmental-exposure; Exposure-assessment; Exposure-levels; Exposure-methods; Microbiology; Microscopic-analysis; Molecular-biology; Molecular-structure; Nanotechnology; Occupational-exposure; Particulates; Risk-analysis; Risk-factors; Standards; Statistical-analysis; Toxic-effects; Toxicology
Journal of Occupational and Environmental Medicine
University of Pittsburgh at Pittsburgh