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Self-reported medical conditions in perfluorooctanesulfonyl fluoride manufacturing workers.

Authors
Grice-MM; Alexander-BH; Hoffbeck-R; Kampa-DM
Source
J Occup Environ Med 2007 Jul; 49(7):722-729
NIOSHTIC No.
20037597
Abstract
Objective: To evaluate whether some cancers, other conditions, and pregnancy outcomes were related to occupational perfluorooctane sulfonate (PFOS) exposure. Methods: We surveyed current and former employees of a perfluorooctanesulfonyl fluoride production facility, using a self-administered questionnaire to ascertain several cancers and health conditions. Female cohort members also completed a brief pregnancy history. We requested medical records to validate reported melanoma, breast, prostate, and colon cancers. PFOS exposure was estimated based on a job exposure matrix up to the year of the diagnosis of the condition. Results: Of the 1895 eligible participants, 1400 questionnaires were returned. No association was observed between working in a PFOS-exposed job and the risk of any of the surveyed conditions. Conclusion: We observed no association between working in a PFOS-exposed job and several cancers, common health conditions, and birth weight.
Keywords
Biological-effects; Biological-systems; Breast-cancer; Cancer-rates; Chemical-properties; Cytology; Demographic-characteristics; Environmental-exposure; Environmental-factors; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Health-surveys; Mathematical-models; Medical-monitoring; Occupational-exposure; Occupational-hazards; Pregnancy; Quantitative-analysis; Questionnaires; Reproduction; Reproductive-system; Reproductive-system-disorders; Risk-analysis; Risk-factors; Statistical-analysis; Surveillance-programs; Work-areas; Work-environment; Worker-health
Contact
Bruce H. Alexander, PhD, University of Minnesota School of Public Health, Mayo MMC 807, 420 Delaware St. SE, Minneapolis, MN 55455
CODEN
JOEMFM
Publication Date
20070701
Document Type
Journal Article
Email Address
balex@umn.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008434
Issue of Publication
7
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
MN
Performing Organization
University of Minnesota Twin Cities
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