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Urinary bisphenol A concentrations and ovarian response among women undergoing IVF.

Authors
Mok-Lin-E; Ehrlich-S; Williams-PL; Petrozza-J; Wright-DL; Calafat-AM; Ye-X; Hauser-R
Source
Int J Androl 2010 Apr; 33(2):385-393
NIOSHTIC No.
20037595
Abstract
Bisphenol A (BPA) is a synthetic chemical used in the manufacture of materials present in many common consumer products. In experimental animals, BPA caused oocyte aneuploidy and reduced production of oestradiol. In a prospective cohort study, we investigated the association between urinary BPA concentrations and ovarian response among women undergoing in vitro fertilization (IVF) at the Massachusetts General Hospital (MGH) Fertility Center. The geometric mean of two specific-gravity (SG) adjusted urinary BPA concentrations collected during each IVF cycle was used as the cycle-specific BPA exposure level. BPA concentrations were measured using online solid phase extraction coupled to isotope dilution-high-performance liquid chromatography-tandem mass spectrometry. Peak serum oestradiol was measured using the Elecsys Estradiol II immunoassay kit. Multivariable mixed effect models and Poisson regression models adjusting for correlation between multiple IVF cycles in the same woman were used to evaluate the association between urinary BPA concentrations and ovarian response, adjusting for age, BMI and day 3 follicle stimulating hormone (FSH) levels, a clinical measure of ovarian reserve. Urinary BPA concentrations were measured in 84 women (mean age 35.6 years) undergoing 112 IVF cycles; 23 women (27%) contributed more than one IVF cycle. BPA concentrations ranged from <0.4 to 25.5 microg/L (geometric mean 2.52 +/- SD 3.2); 15% of urine samples had concentrations <0.4 microg/L. Peak serum oestradiol levels correlated with the total number of oocytes retrieved per cycle (r = 0.65, p < 0.001). For each log unit increase in SG-BPA, there was an average decrease of 12% (95% CI: 4, 23%; p = 0.007) in the number of oocytes retrieved and an average decrease of 213 pg/ml (95% CI: -407, -20; p = 0.03) in peak oestradiol. BPA was detected in the urine of the majority of women undergoing IVF, and was inversely associated with number of oocytes retrieved and peak oestradiol levels.
Keywords
Women; Urinalysis; Exposure-levels; In-vivo-study; Reproductive-effects; Reproductive-hazards; Reproductive-system; Statistical-analysis; Author Keywords: bisphenol A; in vitro fertilization; human oestradiol; oocyte
Contact
Russ Hauser, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
CODEN
IJANDP
CAS No.
80-05-7
Publication Date
20100401
Document Type
Journal Article
Email Address
rhauser@hsph.harvard.edu
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008578
Issue of Publication
2
ISSN
0105-6263
Source Name
International Journal of Andrology
State
GA; MA
Performing Organization
Harvard University, School of Public Health, Boston, Massachusetts
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