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Monitoring method for surface contamination caused by selected antineoplastic agents.

Authors
Larson-RR; Khazaeli-MB; Dillon-HK
Source
Am J Health Syst Pharm 2002 Feb; 59(3):270-277
NIOSHTIC No.
20037556
Abstract
A method of evaluating surface contamination caused by selected antineoplastic agents was studied. The antineoplastic agents tested were cyclophosphamide, ifosfamide, doxorubicin hydrochloride, fluorouracil, and paclitaxel. Each agent was reconstituted and prepared as a stock solution. A 0.1-mL portion of each solution was spread evenly over a 600-cm2 area of a stainless steel surface, a resin countertop surface, and a vinyl flooring surface. After drying, the surfaces were wiped with each of two types of commercially available wiping materials (What-man no. 42 filters and Kimberly-Clark Kimwipes). A blend of methanol, acetonitrile, and buffered water was used both as the wetting agent for wiping the surfaces and as a desorbing solution. The desorbate was analyzed for drug concentration by reverse-phase high-performance liquid chromatography (HPLC). Mean +/- S.D. percent total recovery ranged from 72.4% +/- 17.6% to 95.3% +/- 2.9% for the vinyl surface wiped with filters, 91.5% +/- 5.4% to 104.7% +/- 0.8% for the resin surface wiped with filters, 73.9% +/- 2.3% to 95.3% +/- 1.7% for the stainless steel surface wiped with filters, and 18.2% +/- 1.4% to 372.8% +/- 8.0% for the stainless steel surface wiped with Kimwipes. Results were best for ifosfamide and cyclophosphamide. Kimwipes were deemed ineffective for this monitoring method because an ingredient interfered with the quantitative analytical tests. A wipe-sampling, desorption, and HPLC method for monitoring surface contamination by selected antineoplastic agents was sufficiently accurate and sensitive to evaluate surfaces typically found in both the pharmacy and drug administration areas of oncology treatment facilities.
Keywords
Antineoplastic-agents; Drugs; Liquid-chromatography; Surface-properties; Stainless-steel; Vinyl-plastics; Resins; Oncogenic-agents; Author Keywords: Antineoplastic agents; Chromatography; liquid; Contamination; Cyclophosphamide; Doxorubicin hydrochloride; Fluorouracil; Ifosfamide; Methodology; Paclitaxel; Solvents; Tests
Contact
Dr. Larson at the Department of Environmental Health Sciences, School of Public Health, The University of Alabama at Birmingham, RPHB 317, 1530 3rd Avenue South, Birmingham, AL 35294-0022
CODEN
ASHPEK
CAS No.
50-18-0; 33069-62-4; 3778-73-2; 23214-92-8; 51-21-8
Publication Date
20020201
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008414
Issue of Publication
3
ISSN
1079-2082
Source Name
American Journal of Health-System Pharmacy
State
AL; UT
Performing Organization
University of Utah, Salt Lake City, Utah
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