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Development of an HPLC method for simultaneous analysis of five antineoplastic agents.

Authors
Larson-RR; Khazaeli-MB; Dillon-HK
Source
Appl Occup Environ Hyg 2003 Feb; 18(2):109-119
NIOSHTIC No.
20037544
Abstract
Simultaneous analysis of common antineoplastic agents potentially hazardous to healthcare workers is of much interest for the evaluation of the overall health risk to these workers. Such analysis could be applied to both air and surface monitoring samples to provide a broader indication of risk to combinations of these agents. It was determined that the ability to simultaneously evaluate five frequently used, potentially hazardous agents was sufficient for general evaluation of exposures to healthcare workers. The approach used to select the five agents was to obtain a list of the agents used most frequently in both a cancer hospital and an outpatient cancer treatment center, then review the list to determine which agents were potentially more hazardous to human health. From these reviews, it was decided to attempt to develop an analytical method able to detect and quantify the presence of 5-fluorouracil, ifosfamide, cyclophosphamide, doxorubicin HCl, and paclitaxel. A reverse-phase high performance liquid chromatograph (HPLC) with a Waters Symmetry C8 column and a UV wavelength of 195 nm was selected for method development. The mobile phase was 22.75 percent acetonitrile in water buffered to a pH of 6.0. The HPLC analytical method developed is able to detect all five agents of interest, and at minimum detectable concentrations of 0.5-microg/mL for each of the five agents.
Keywords
Drugs; Antineoplastic-agents; Hazardous-materials; Health-care-facilities; Health-care-personnel; Health-hazards; Occupational-hazards; Author Keywords: Antineoplastics; HPLC; Analysis; Fluorouracil; Ifosfamide; Cyclophosphamide; Doxorubicin; Paclitaxel
CODEN
AOEHE9
CAS No.
50-18-0; 33069-62-4; 3778-73-2; 23214-92-8; 51-21-8
Publication Date
20030201
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2003
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008414
Issue of Publication
2
ISSN
1047-322X
Source Name
Applied Occupational and Environmental Hygiene
State
AL; UT
Performing Organization
University of Utah, Salt Lake City, Utah
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