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Comparison of patella lead with blood lead and tibia lead and their associations with neurobehavioral test scores.

Authors
Dorsey-CD; Lee-BK; Bolla-KI; Weaver-VM; Lee-SS; Lee-GS; Todd-AC; Shi-W; Schwartz-BS
Source
J Occup Environ Med 2006 May; 48(5):489-496
NIOSHTIC No.
20037533
Abstract
OBJECTIVE: Lead exposure in adults is associated with worse cognitive function in cross-sectional and longitudinal studies. Previous studies have mainly examined relations with blood lead or cortical bone lead; few have examined trabecular bone lead. METHODS: We performed a cross-sectional analysis of the relations of patella lead and other lead biomarkers with measures of neurobehavioral and peripheral nervous system function in 652 lead workers. RESULTS: Patella lead was found to be associated with worse performance on seven of 19 tests of manual dexterity, sensory vibration threshold, and depressive symptoms. The associations of patella lead with cognitive function were essentially similar to those with blood lead or tibia lead but of somewhat lower magnitude. CONCLUSIONS: In this study, measurement of patella lead did not aid causal inference regarding cognitive effects when compared with blood lead and tibia lead.
Keywords
Lead-compounds; Exposure-assessment; Exposure-levels; Biomarkers; Men; Nervous-system; Nervous-system-disorders; Poisons; Age-groups; Humans; Blood-poisoning; Blood-samples
Contact
Byung-Kook Lee, MD, Soonchunhyang University, College of Medicine, 646 Eupnae-ri, Shinchang-myun, Asan-Si, Choongnam, 336-745, Korea
CODEN
JOEMFM
CAS No.
7439-92-1
Publication Date
20060501
Document Type
Journal Article
Email Address
bklee@sch.ac.kr
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
5
ISSN
1076-2752
Source Name
Journal of Occupational and Environmental Medicine
State
MD; NY
Performing Organization
Johns Hopkins University
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