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Biomonitoring for farm families in the Farm Family Exposure Study.

Authors
Mandel-JS; Alexander-BH; Baker-BA; Acquavella-JF; Chapman-P; Honeycutt-R
Source
Scand J Work, Environ & Health 2005 Jan; 31(Suppl 1):98-104
NIOSHTIC No.
20037497
Abstract
OBJECTIVES: The Farm Family Exposure Study was conducted to evaluate real-world pesticide exposure for farmers, spouses, and children. METHODS: Eligible farm families from Minnesota and South Carolina were randomly selected from a roster of licensed private pesticide applicators. Eligibility required that the family include a farmer, spouse, and at least one child between the ages of 4 and 17 years, that the family live on the farm, that the farmer planned to apply one of the target pesticides [glyphosate, chlorpyrifos, 2,4-dichlorophenoxy acetic acid (2,4-D)] to at least 10 acres (4.1 hectares) of land within 1 mile (1.6 kilometers) of the house. For each family member, geometric means were calculated for 24-hour composite urinary samples, with a 1 ppb (part per billion) limit of detection, the day before, the day of, and for 3 days after the application. RESULTS: For the farmers, the peak geometric mean concentrations were 3 ppb for glyphosate, 64 ppb for 2,4-D, and 19 ppb for the primary chlorpyrifos metabolite. For the spouses and children, the percentage with detectable values varied by chemical, although the average values for each chemical did not vary during the study period. The applicators had the highest urine pesticide concentrations, children had much lower values, and spouses had the lowest values. Exposure to family members was largely, though not exclusively, determined by the degree of direct contact with the application process. The exposure profile varied for the three chemicals for each family member. CONCLUSIONS: The data of this study indicate the importance of chemical-specific considerations when exposure assessments are planned in epidemiologic studies.
Keywords
Age-factors; Age-groups; Agricultural-chemicals; Agricultural-industry; Agricultural-machinery; Agricultural-processes; Agriculture; Chemical-hypersensitivity; Chemical-reactions; Children; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Families; Farmers; Mathematical-models; Nervous-system-disorders; Neurological-reactions; Pathology; Pesticides-and-agricultural-chemicals; Quantitative-analysis; Questionnaires; Statistical-analysis; Toxic-effects; Work-environment; Work-performance; Work-practices; Author Keywords: 2,4-dichlorophenoxyacetic acid; agriculture; biomonitoring; child; chlorpyrifos; Farm Family Exposure Study; glyphosate; pesticide; spouse
Contact
Dr Jack S Mandel, Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, NE, Atlanta, GA 30322
CODEN
SWEHDO
CAS No.
1071-83-6; 94-75-7; 2921-88-2
Publication Date
20050101
Document Type
Journal Article
Email Address
jsmande@sph.emory.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008434
ISSN
0355-3140
Source Name
Scandinavian Journal of Work, Environment and Health
State
MN; GA
Performing Organization
University of Minnesota Twin Cities
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