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Persistent neuropathy and hyperkeratosis from distant arsenic exposure.

Authors
Baker-BA; Topliff-AR; Messing-RB; Durkin-D; Johnson-JS
Source
J Agromed 2006 May; 10(4):43-54
NIOSHTIC No.
20037493
Abstract
The purpose of this case series is to assess long-term sequelae of arsenic exposure in a cohort acutely exposed to arsenic in drinking water from a well dug into a landfill containing arsenical pesticides. Ten of the 13 individuals (or next of kin) in the initial study agreed to participate in the follow-up study. Next of kin provided questionnaire data and released medical information on the three individuals who had died. The remaining seven cohort members were assessed by an interview, questionnaire, detailed physical examination and sensory nerve testing. Available medical records were obtained and reviewed. Sensory testing was performed using an automated electrodiagnostic sensory Nerve Conduction Threshold (sNCT) evaluation. Sensory complaints and electrodiagnostic findings consistent with polyneuropathy were found in a minority (3/7) of subjects 28 years after an acute toxic arsenic exposure. Two of the seven patients examined (1 of 3 with neuropathic findings) also had hyperkeratotic lesions consistent with arsenic toxicity and one of the patients had hyperpigmentation on their lower extremities possibly consistent with arsenic toxicity.
Keywords
Agricultural-chemicals; Agricultural-industry; Agricultural-processes; Agriculture; Chemical-hypersensitivity; Chemical-reactions; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-methods; Mortality-surveys; Nervous-system-disorders; Nervous-system-function; Neurological-reactions; Pathology; Pesticides-and-agricultural-chemicals; Questionnaires; Toxic-effects; Toxicopathology Water-sampling; Author Keywords: Arsenic; neuropathy; polyneuropathy; hyperkeratosis
Contact
Beth A. Baker, Occupational and Environmental Medicine, Regions Medical Center, 640 Jackson St, St. Paul, MN 55101
CAS No.
7440-38-2
Publication Date
20060501
Document Type
Journal Article
Email Address
beth.a.baker@healthpartners.com
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008434
Issue of Publication
4
ISSN
1059-924X
Source Name
Journal of Agromedicine
State
MN
Performing Organization
University of Minnesota Twin Cities
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