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Major rat allergens causing laboratory animal allergies.

Authors
Bledsoe-T; Lewis-D
Source
Clin Lab Sci 1990 May-Jun; 3(3):219
NIOSHTIC No.
20037454
Abstract
Occupational allergies can result in lost time at work and a change in position or vocation by the employee. Studies concerning the prevalence of laboratory animal allergies (LAA) have estimated the incidence of LAA among animal care workers to be eleven and thirty per cent. The rat is the most frequently reported cause of LAA (72.2%) and this study identifies the antigenic components of two major sources of rat protein: rat urine and rat epithelia. Four epithelial protein fractions and three urinary protein fractions were identified by column chromatorgaphy. These fractions were determined to have marked antigeneic activity by the radioallergosorbent (RAST) inhibition assay. The results demonstrated that the rat urinary and the rat epithelial extracts had similiar antigenic components but also each had antigenic components unique to itself.
Keywords
Allergic-reactions; Allergens; Allergies; Laboratory-animals; Laboratories
Publication Date
19900501
Document Type
Journal Article
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0894-959X
NIOSH Division
DRDS
Source Name
Clinical Laboratory Science
State
WV
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