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Effects of humidity and other factors on the generation and sampling of a coronavirus aerosol.

Authors
Kim-SW; Ramakrishnan-MA; Raynor-PC; Goyal-SM
Source
Aerobiologia 2007 Jun; 23(4):239-248
NIOSHTIC No.
20037435
Abstract
Suspensions of transmissible gastroenteritis virus (TGEV), a porcine coronavirus, were nebulized at rates of 0.1-0.2 ml/min into moving air using a Collison nebulizer or a plastic medical nebulizer operating at pressures ranging from 7 to 15 psi. The airborne viruses were collected on heating, ventilating, and air conditioning (HVAC) filters in an experimental apparatus and also sampled upstream of these test filters using AGI-30 and BioSampler impinger samplers. To study the effects of relative humidity (RH) on TGEV collection by the filters and samplers, the virus was nebulized into air at 30, 50, 70, and 90% RH. There were no significant changes in virus titer in the nebulizer suspension before and after nebulization for either nebulizer at any of the pressures utilized. Aerosolization efficiency - the ratio of viable virus sampled with impingers to the quantity of viable virus nebulized - decreased with increasing humidity. BioSamplers detected more airborne virus than AGI-30 samplers at all RH levels. This difference was statistically significant at 30 and 50% RH. Nebulizer type and pressure did not significantly affect the viability of the airborne virus. Virus recovery from test filters relative to the concentration of virus in the nebulizer suspension was less than 10%. The most and the least virus were recovered from filter media at 30% and 90% RH, respectively. The results suggest that TGEV, and perhaps other coronaviruses, remain viable longer in an airborne state and are sampled more effectively at low RH than at high humidity.
Keywords
Aerosol-particles; Air-conditioning-equipment; Air-contamination; Air-filters; Air-pressure; Air-sampling; Biohazards; Biological-effects; Environmental-factors; Exposure-assessment; Exposure-levels; Exposure-methods; Filters; Inhalants; Inhalation-studies; Laboratory-testing; Lung-irritants; Mathematical-models; Particle-aerodynamics; Particulates; Particulate-sampling-methods; Physiological-effects; Quantitative-analysis; Risk-analysis; Risk-factors; Statistical-analysis; Ventilation-equipment; Ventilation-systems; Viral-diseases; Viral-infections; Author Keywords: Bioaerosol; Coronavirus; Humidity; Nebulizer; Sampling; TGEV; Virus
Contact
S. W. Kim & P.C. Raynor, Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Mayo MC 807, 420 Delaware St. SE, Minneapolis, MN 55455
CODEN
AROBFT
Publication Date
20070601
Document Type
Journal Article
Email Address
praynor@umn.edu
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008434
Issue of Publication
4
ISSN
0393-5965
Source Name
Aerobiologia
State
MN
Performing Organization
University of Minnesota Twin Cities
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