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Cellular and molecular mechanisms of asbestosis.

Authors
Mossman-BT; Gilbert-R; Doherty-J; Shatos-MA; Marsh-J; Cutroneo-K
Source
Chest 1986 Mar; 89(3)(Suppl):160S-161S
NIOSHTIC No.
20037423
Abstract
Occupational and experimental exposure to asbestos is associated with the development of peribronchiolar and interstitial pulmonary fibrosis. Like other asbestosassociated diseases of the respiratory tract (ie, mesothelioma and bronchogenic carcinoma), asbestosis appears to involve alterations in differentiation and proliferation of affected cell types. Whether the disease process involves either an increase in replication of fibroblasts in the lung or an enhanced ability of individual fibroblasts to produce more collagen or both is uncertain. To address this question, we used a combination of in vitro and in vivo approaches.
Keywords
Asbestos-fibers; Lung-cells; Cell-damage; Cell-cultures; Cytotoxic-effects; Respiratory-system-disorders; In-vitro-studies; Laboratory-animals; Animal-studies; In-vivo-study; Asbestosis
CODEN
CHETBF
Publication Date
19860301
Document Type
Journal Article
Funding Amount
97200
Funding Type
Grant
Fiscal Year
1986
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00007
Issue of Publication
3
ISSN
0012-3692
Source Name
Chest
State
VT
Performing Organization
University of Vermont & St Agric College, Burlington, Vermont
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