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Antibodies to alcalase after industrial exposure.

Authors
Berson-SA; Yalow-RS; Saito-T; Selikoff-IJ
Source
N Engl J Med 1971 Apr; 284(13):688-690
NIOSHTIC No.
20037413
Abstract
Nineteen of 22 workers in a detergent factory, exposed to an enzyme additive ("Alcalase") derived from Bacillus subtilis cultures, had circulating antibodies to a component of this material; the antibodies reacted also with a component of a purified subtilisin ("Carlsberg") preparation. None of 40 unexposed subjects had this antibody. In two guinea pigs immunized with Alcalase, antibodies developed that reacted with the same component of Alcalase that reacted with the human antiserums and with similar components of two purified subtilisin preparations ("Carlsberg" and "Novo").
Keywords
Detergent-enzymes; Detergent-industry; Detergents; Humans; Laboratory-animals; Animal-studies; Enzyme-activity; Antibody-response
CODEN
NEJMAG
Publication Date
19710401
Document Type
Journal Article
Funding Amount
207338
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-000305
Issue of Publication
13
ISSN
0028-4793
Source Name
New England Journal of Medicine
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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