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Talc pneumoconiosis: significance of sublight microscopic mineral particles.

Authors
Miller-A; Teirstein-AS; Bader-ME; Bader-RA; Selikoff-IJ
Source
Am J Med 1971 Mar; 50(3):395-402
NIOSHTIC No.
20037411
Abstract
Described herein is a patient with talc pneumoconiosis whose symptoms began fifteen years after heavy exposure and who progressed to massive fibrosis and death seven years later from cardiopulmonary insufficiency. Studies of pulmonary function showed restriction of lung volumes, loss of pulmonary compliance and increased venous admixture with moderate hypoxemia. Cardiac catheterization revealed pulmonary hypertension. Lung tissue was analyzed for mineral content by x-ray diffraction and electron microscopy, which established the presence of talc in the absence of histologic demonstration of mineral particles by conventional light microscopy. The significance of submicroscopic talc particles in the production of disease is demonstrated and related to similar findings in asbestosis.
Keywords
Talc-dust; Pneumoconiosis; Pulmonary-system-disorders; Respirable-dust; Respiratory-system-disorders; Mineral-dusts; Particulate-dust; Respirable-dust; Dust-inhalation; Dust-exposure; Dust-particles
Contact
Dr. Albert Miller, Pulmonary Function Laboratory, The Mount Sinai Hospital, 100th Street and Fifth Avenue, New York, New York 10029
CODEN
AJMEAZ
CAS No.
14807-96-6
Publication Date
19710301
Document Type
Journal Article
Funding Amount
207338
Funding Type
Grant
Fiscal Year
1971
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-000305
Issue of Publication
3
ISSN
0002-9343
Source Name
The American Journal of Medicine
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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