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Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam.

Authors
Kang-HK; Dalager-NA; Needham-LL; Patterson-DG Jr.; Lees-PSJ; Yates-K; Matanoski-GM
Source
Am J Ind Med 2006 Nov; 49(11):875-884
NIOSHTIC No.
20037401
Abstract
BACKGROUND: U.S. Army Chemical Corps veterans handled and sprayed herbicides in Vietnam resulting in exposure to Agent Orange and its contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This study examined the long-term health effects associated with herbicide exposure among these Vietnam veterans. METHODS: A health survey of these 1,499 Vietnam veterans and a group of 1,428 non-Vietnam veterans assigned to chemical operations jobs was conducted using a computer-assisted telephone interview (CATI) system. Exposure to herbicides was assessed by analyzing serum specimens from a sample of 897 veterans for dioxin. Logistic regression analyses were used to estimate the risk of selected medical outcomes associated with herbicide exposure. RESULTS: Odds ratios for diabetes, heart disease, hypertension, and chronic respiratory disease were elevated, but not significantly (P>0.05) for those who served in Vietnam. However, they were significantly elevated among those Vietnam veterans who sprayed herbicides: diabetes, odds ratio (OR)=1.50 (95% confidence interval [95%CI]=1.15-1.95); heart disease, OR=1.52 (1.18-1.94); hypertension, OR=1.32 (1.08-1.61); and chronic respiratory condition, OR=1.62 (1.28-2.05). Hepatitis was associated with Vietnam service, but not with herbicide application. CONCLUSIONS: Vietnam veterans who were occupationally exposed to herbicide experienced a higher risk of several chronic medical conditions relative to other non-Vietnam veterans. A potential selection bias is of concern. However, there were relatively high participation rates in both the Vietnam and non-Vietnam veteran groups, and the prevalence rates of some of these medical conditions among non-Vietnam veterans were comparable to general populations. Therefore, self-selection factors are considered unlikely to have biased the study results.
Keywords
Herbicides; Exposure-levels; Exposure-assessment; Chemical-warfare-agents; Chemical-reactions; Dioxides; Dioxins; Poisons; Author Keywords: Agent Orange; Diabetes; Dioxin; Herbicide; Veterans; Vietnam
Contact
Dr. Han K. Kang, Director, Environmental Epidemiology Service (135), Department of Veterans Affairs, 810 Vermont Ave. NW,Washington, DC 20420
CODEN
AJIMD8
CAS No.
1746-01-6
Publication Date
20061101
Document Type
Journal Article
Email Address
han.kang@va.gov
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008428
Issue of Publication
11
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
DC; GA; MD
Performing Organization
Johns Hopkins University
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