Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Thyroid disease associated with exposure to the Nevada nuclear weapons test site radiation: a reevaluation based on corrected dosimetry and examination data.

Authors
Lyon-JL; Alder-SC; Stone-MB; Scholl-A; Reading-JC; Holubkov-R; Sheng-X; White-GL Jr.; Hegmann-KT; Anspaugh-L; Hoffman-FO; Simon-SL; Thomas-B; Carroll-R; Meikle-AW
Source
Epidemiology 2006 Nov; 17(6):604-614
NIOSHTIC No.
20037327
Abstract
Background: A study was begun in 1965 to 1966 to determine whether children exposed to radioactive iodine from nuclear weapons testing at the Nevada Test Site from 1951 through 1962 were at higher risk of thyroid disease. In 1993, we reported that among those examined in 1985 to 1986 (Phase II) there was an association between radiation from the Nevada Test Site and thyroid neoplasms. Methods: We reevaluated the relationship between exposure to Nevada Test Site fallout and thyroid disease using newly corrected dose estimates and disease outcomes from the Phase II study. A prospective cohort of school children 12 to 18 years old living in Utah, Nevada, and Arizona was first examined for thyroid disease in 1965 to 1966 and reexamined in 1985 to 1986. In the Phase II report, 2497 subjects formed the basis for this analysis. Thyroid disease, including thyroid neoplasms and thyroiditis, was expressed as cumulative incidence and risk ratios (RRs) with a dose-response expressed as excess risk ratio (ERR/Gy). Results: The RR between thyroid radiation dose in the highest dose group and thyroid neoplasms increased from 3.4 (in the earlier analysis) to 7.5. The RR for thyroiditis increased from 1.1 to 2.7 with an ERR/Gy of 4.9 (95% confidence interval = 2.0 to 10.0). There were too few malignant thyroid neoplasms to estimate risk. Conclusions: Persons exposed to radioactive iodine as children have an increased risk of thyroid neoplasms and autoimmune thyroiditis up to 30 years after exposure.
Keywords
Thyroid-gland; Thyroid-gland-disorders; Children; Radioactive-contaminants; Radioactive-contamination; Radioactive-fallout; Nuclear-energy; Nuclear-radiation; Nuclear-wastes; Neoplasms; Dose-response; Exposure-assessment; Risk-analysis; Radiation; Radiation-effects; Radiation-exposure; Radiation-injury
Contact
Joseph L. Lyon, Department of Family and Preventive Medicine, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108
CODEN
EPIDEY
CAS No.
7553-56-2
Publication Date
20061101
Document Type
Journal Article
Email Address
jlyon@dfpm.utah.edu
Funding Type
Grant; Cooperative Agreement
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008414; Cooperative-Agreement-Number-U50-CCU-816245
Issue of Publication
6
ISSN
1044-3983
Source Name
Epidemiology
State
UT; TN; MD; TX
Performing Organization
University of Utah, Salt Lake City, Utah
TOP