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The infectious dose of francisella tularensis (tularemia).

Authors
Jones-RM; Nicas-M; Hubbard-A; Sylvester-MD; Reingold-A
Source
Appl Biosafety 2005 Apr; 10(4):227-239
NIOSHTIC No.
20037262
Abstract
Quantitatively estimating an individual's risk of infection by an airborne pathogen requires knowledge of the expected dose and the pathogen's infectious dose. Based on our review of the published literature on tularemia, we conclude that the infectious dose of Francisella tularensis varies among individuals, but that a substantial proportion of the population can be infected by a single bacillus. We also conclude that infection can be initiated by inhaling bacilli carried on respirable particles (diameters less than 10 um) or nonrespirable particles (diameters between 10 um and 100 um). Regression analyses based on two-parameter Weibull and lognormal models of human inhalation dose-infection data aggregated across three studies indicate that approximately 30% of individuals who inhale a single F. tularensis bacillus will develop tularemia. Further, when the organism is carried on particles with diameters on the order of 1 um, it is estimated that the deposition of a single bacillus produces infection in 40% to 50% of individuals; thus, when F. tularensis is carried on respirable particles, the estimated ID50 via inhalation is close to one deposited bacillus. These results are consistent with separate analyses using nonparametric methods and with experimental animal models in which infection is observed after injection of a single bacillus. The risk of person-to-person transmission of tularemia is generally considered negligible, perhaps due to a low concentration of F. tularensis in respiratory fluids. However, viable F. tularensis bacilli are present in human respiratory fluids, and can be carried in inspirable particles (diameters less than 100 um) which are emitted during coughs and sneezes.
Keywords
Aerosol-particles; Aerosols; Airborne-particles; Air-contamination; Bacteria; Bacterial-disease; Bacterial-dusts; Bacterial-infections; Biological-effects; Biological-function; Exposure-assessment; Exposure-levels; Exposure-methods; Health-hazards; Immune-reaction; Immune-system; Inhalants; Inhalation-studies; Mathematical-models; Medical-surveys; Pathogenesis; Pathogenicity; Pathogens; Physiological-effects; Physiological-measurements; Physiological-response; Quantitative-analysis; Risk-analysis; Risk-factors; Safety-measures; Safety-practices; Statistical-analysis; Work-environment
Publication Date
20050401
Document Type
Journal Article
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008429
Issue of Publication
4
ISSN
1535-6760
Source Name
Applied Biosafety
State
CA
Performing Organization
University of California, Berkeley
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