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Lamotrigine-induced seizures in a child: case report and literature review.

Authors
Thundiyil-JG; Anderson-IB; Stewart-PJ; Olson-KR
Source
Clin Toxicol 2007 Mar; 45(2):169-172
NIOSHTIC No.
20037246
Abstract
INTRODUCTION: Lamotrigine is an antiepileptic agent. There is only one previous report of a seizure associated with lamotrigine overdose with laboratory confirmation (a 2-year-old girl, lamotrigine level of 3.8 mg/L). CASE REPORT: A healthy 19-month-old boy ingested an unknown amount of his sister's lamotrigine tablets. Twenty minutes later, the child experienced generalized seizure activity lasting 10 seconds, followed by another brief self-limited seizure. Vitals signs: heart rate 152-207 bpm crying, respiratory rate 26 /min, temperature 95.7 degrees F, and pupils 3mm. The one-hour lamotrigine level = 20.3 mg/L. The child was discharged 24 hours later. LITERATURE REVIEW: Six previous case reports of lamotrigine poisoning with serum levels, as well as a retrospective review of lamotrigine exposures, are discussed. CONCLUSION: A case of lamotrigine-induced seizures in a pediatric patient is reported, with a level approximately five times the upper limit of the therapeutic range. The pediatric population may be at increased risk of seizures following lamotrigine poisoning, and serum levels may not be clinically useful for predicting outcome after overdose.
Keywords
Age-groups; Biological-effects; Chemical-hypersensitivity; Children; Drug-Interaction; Drugs; Emergency-care; Emergency-treatment; Exposure-assessment; Exposure-levels; Exposure-methods; Health-hazards; Medical-monitoring; Medical-treatment; Neurological-reactions; Neurological-system; Physiological-effects; Physiological-measurements; Physiological-response; Poison-control; Poisons; Risk-analysis; Risk-factors; Statistical-analysis; Author Keywords: Lamotrigine; Seizure; Pediatric; Poisoning
Contact
Josef G. Thundiyil, School of Medicine, University of California, San Francisco, UCSF box 1369, San Francisco, CA 94143-1369
CODEN
CTPPA5
Publication Date
20070301
Document Type
Journal Article
Email Address
joseft@mindspring.com
Funding Type
Grant
Fiscal Year
2007
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008429
Issue of Publication
2
ISSN
1556-3650
Source Name
Clinical Toxicology
State
CA; FL
Performing Organization
University of California, Berkeley
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