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Is self-rated health associated with blood immune markers in healthy individuals?

Authors
Nakata-A; Takahashi-M; Otsuka-Y; Swanson-NG
Source
Int J Behav Med 2010 Sep; 17(3):234-242
NIOSHTIC No.
20037239
Abstract
Background: Although self-rated health (SRH) has been established as a robust predictor of morbidity and mortality, the immunological mechanisms underpinning this relationship are poorly understood. Purpose: This study examined the association of SRH with humoral and cellular immune markers in healthy individuals who reported no physical illnesses. Method: A total of 116 healthy Japanese white-collar employees (79 women and 37 men) at a pharmaceutical company, aged 23.62 (mean 32) years, underwent a blood draw for the measurement of circulating immune (T, B, and natural killer) cells, inflammatory cytokines (interleukin-6 and tumor necrosis factor-alpha), and plasma immunoglobulin G (IgG) and completed a health survey including SRH. The question regarding SRH ranged from "very good" (coded 1) to "very poor" (coded 5). Hierarchical multiple regression analysis was carried out to calculate the relationship between SRH and immune markers. Results: In this sample, poor SRH was positively correlated with B (CD19+) cell numbers (beta=0.260, p<0.05) and IgG levels (beta=0.335, p<0.01) even after adjusting for depressive symptoms, age, education, marital status, smoking, alcohol consumption, physical activity, body mass index, sex, and sex x SRH interaction. The interaction between SRH and sex on the immune markers was not significant. Conclusion: Although the connection between SRH and immune markers was not strong in this context, the results suggest that poor SRH may be associated with reduced humoral immune system capacity to respond to new/latent challenges. The results provide some support for the immunological basis of SRH in healthier individuals.
Keywords
Health-surveys; Psychological-responses; Immune-system; Immunoglobulins; Immunological-tests; Blood-tests; Biomarkers; Cell-function; Cellular-reactions; Immunological-tests; Demographic-characteristics; Statistical-analysis; Author Keywords: Self-rated health; Immune system; B cell; IgG; Cytokine; Psychoimmunology
Contact
Akinori Nakata, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C24, Cincinnati, OH 45226, USA
CODEN
IJBMFT
Publication Date
20100901
Document Type
Journal Article
Email Address
cji5@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1070-5503
NIOSH Division
DART
Priority Area
Services
Source Name
International Journal of Behavioral Medicine
State
OH
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