Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Silicosis mortality with respiratory tuberculosis in the United States, 1979-2006.

Authors
Nasrullah-M; Mazurek-JM; Wood-JM; Bang-K; Kreiss-K
Source
Am J Respir Crit Care Med 2010 May; 181(Meeting Abstracts):A4699
NIOSHTIC No.
20037200
Abstract
Rationale: Silicosis, a preventable occupational lung disease is associated with various diseases including tuberculosis (TB). Although, deaths with silicosis and respiratory tuberculosis (TB) in the United States have considerably declined, they still occur. Tuberculin-positive persons with silicosis have 30 times higher risk of developing active TB as compared to a control population. Methods: We describe silicosis-TB deaths using the 1979-2006 National Center for Health Statistics mortality data for decedents aged greater than or equal to 25 years. We calculated proportionate mortality ratios (PMRs) using available information on the decedents' industry and occupation reported from 26 states for 1985-1999. Results: Of 7,505 deaths with silicosis, 311 (4.1%) had concurrent TB; 248 (79.9%) were greater than or equal to 65 years; 306 (98.4%) were males, and 221 (71.1%) were whites. Silicosis-TB deaths were more likely to occur among silicosis decedents aged 25-44 than among those aged greater than or equal to 45 years (8.0% vs. 4.1%; p=0.02) and among black silicosis decedents than among those of all other races (8.0% vs. 3.5%; p<0.01). Silicosis-TB deaths declined 94.3% (p<0.01 for time-related trend) from 21.0 per year during 1979-1983 to 1.2 per year during 2002-2006. Silicosis-TB deaths reported from Ohio (n=35; 11.3%), Pennsylvania (n=33; 10.6%), and Michigan (n=24; 7.7%) accounted for 29.6% of all such deaths in the United States. The highest industry-specific and occupation-specific PMRs for silicosis-TB deaths were associated with the miscellaneous nonmetallic mineral and stone products industry (73.7; 95% CI 33.8.139.8) and the crushing and grinding machine operators occupation (142.3; 95% CI 57.2.293.5). Conclusions Silicosis-TB mortality declined substantially; younger and black workers with silicosis appear to have higher risk of mortality associated with TB. Prevention and control measures for TB and silica exposure have helped in accomplishing this low rate of silicosis-TB in the United States.
Keywords
Age-factors; Age-groups; Airborne-particles; Biological-effects; Biological-monitoring; Breathing; Cell-biology; Cellular-reactions; Diseases; Disease-transmission; Dust-analysis; Dust-exposure; Dust-inhalation; Dust-particles; Dusts; Exposure-assessment; Exposure-levels; Exposure-methods; Immune-system; Immunodiagnosis; Inhalants; Inhalation-studies; Lung; Lung-burden; Lung-cells; Lung-disease; Lung-disorders; Lung-function; Lung-irritants; Men; Mortality-rates; Mortality-surveys; Occupational-diseases; Occupational-exposure; Occupational-hazards; Occupational-health; Occupational-respiratory-disease; Particle-aerodynamics; Particulate-dust; Particulates; Pulmonary-congestion; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders; Quantitative-analysis; Racial-factors; Respirable-dust; Respiratory-hypersensitivity; Respiratory-infections; Respiratory-irritants; Respiratory-system-disorders; Risk-analysis; Risk-factors; Silicosis; Statistical-analysis; Toxic-effects; Work-areas; Work-environment; Worker-health; Work-operations; Work-performance; Workplace-monitoring; Workplace-studies
CODEN
AJCMED
CAS No.
7440-21-3
Publication Date
20100501
Document Type
Abstract
Email Address
snasrullah@cdc.gov
Fiscal Year
2010
NTIS Accession No.
NTIS Price
ISSN
1073-449X
NIOSH Division
DRDS
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV; OH
TOP