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Pesticide metabolism and potential for metabolic interactions.

Authors
Rose-LR; Hodgson-E
Source
J Biochem Mol Toxicol 2005 Aug; 19(4):276-277
NIOSHTIC No.
20037199
Abstract
Studies in whichhuman hepatocytes are exposed to varying concentrations of pesticides indicate that several pesticides are capable of inducing CYP enzymes. Chlorpyrifos, for example, induces isoforms CYP1A1, 1A2, 2B6, and 3A4 to levels five-fold or greater than controls. Permethrin, which was not metabolized in vitro by CYP isoforms, also induced CYP2A6, 2B6, and 3A4 [8]. The implications of the ability of pesticides to induce CYP isoforms in human hepatocytes will require further study; particularly to determine if concentrations necessary for such induction would occur in vivo.
Keywords
Agricultural-chemicals; Agricultural-workers; Agriculture; Chemical-analysis; Chemical-composition; Chemical-deposition; Chemical-extraction; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Chemical-synthesis; Chemical-warfare-agents; Animals; Exposure-assessment; Exposure-levels; Exposure-limits; Exposure-methods; Environmental-contamination; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-health-monitoring; Environmental-pollution; Environmental-protection; Environmental-stress; Epidemiology; Pesticide-industry; Pesticide-residues; Pesticide-strips; Pesticides; Pesticides-and-agricultural-chemicals; Contaminated-food; Humans; Mesothelial-cells; Metabolic-disorders; Metabolic-study; Metabolism; Pharmaceuticals; Pharmacology; Enzymatic-disorders; Enzymatic-effects; Enzyme-activity; Enzyme-complexes; Enzyme-inhibitors; Enzymes; Enzymology; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Sulfates; Sulfhydryls; Sulfides; Sulfites; Sulfonamides; Sulfonates; Sulfoxides; Sulfur-compounds; Sulfur-oxides; Liver; Liver-cancer; Liver-cells; Liver-damage; Liver-disorders; Liver-enzymes; Liver-function; Liver-microsomal-enzymes; Liver-microsomal-metabolism; Liver-microsomes; Liver-tissue; Liver-tumors; Livestock; Esters
Contact
Randy L. Rose, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695
CODEN
JBMTFQ
CAS No.
2921-88-2; 63-25-2
Publication Date
20050801
Document Type
Journal Article
Email Address
randy rose@ncsu.edu
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007551
Issue of Publication
4
ISSN
1095-6670
Source Name
Journal of Biochemical and Molecular Toxicology
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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