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Toxicology of AHS important chemicals.

Authors
Hudgson-E; Rose-LR
Source
J Biochem Mol Toxicol 2005 Jun; 19(3):180-181
NIOSHTIC No.
20037197
Abstract
The chloroacetamide herbicides, alachlor., acetochlor butachlor and metolachlor. have been associated with cancers at various sites in rodents as follows: acetochlor.nasal epithelium, thyroid, liver; butachlor.stomach; alachlor.nasal epithelium, thyroid, stomach; metolachlor.liver. The DNA reactive intermediates are quinone imines generated by metabolic pathways that involve CYP isoforms as well as arylamidase. However, since the metabolism of these chemicals varies between rodents and humans, it is not clear how these results may be extrapolated to humans. Although little is known about the metabolism of the substituted aromatic herbicides dicamba and pendimethalin in humans or surrogate animals, they are of low acute toxicity tomammalsand not previously known to be carcinogenic. However, early results from the AHS associate these chemicals with lung cancer.
Keywords
Agricultural-chemicals; Agricultural-industry; Agricultural-machinery; Agricultural-processes; Agricultural-products; Agricultural-workers; Agriculture; Chemical-composition; Chemical-deposition; Chemical-extraction; Chemical-factory-workers; Chemical-hypersensitivity; Chemical-indicators; Chemical-processing; Chemical-properties; Chemical-reactions; Chemical-structure; Chemical-synthesis; Chemical-warfare-agents; Chronic-degenerative-diseases; Chronic-exposure; Chronic-inflammation; Chronic-toxicity; Acute-exposure; Acute-toxicity; Health-hazards; Health-standards; Animals; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-health-monitoring; Environmental-pollution; Environmental-protection; Environmental-stress; Toxic-effects; Toxic-gases; Toxic-vapors; Toxicology; Toxicopathology; Toxins; Trace-analysis; Humans; Mesothelial-cells; Metabolic-disorders; Metabolic-study; Metabolism; Metabolites; Organo-nitrogen-compounds; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Pesticide-industry; Pesticide-residues; Pesticide-strips; Pesticides; Pesticides-and-agricultural-chemicals; Nephrological-disorders; Nephrotoxicity; Nephrotoxins; Nerve-damage; Neurohormones; Neurological-diseases; Neurological-reactions; Neurological-system; Neuromotor-disorders; Neuromotor-function; Neuromotor-system; Neuromotor-system-disorders; Neuromuscular-function; Neuromuscular-system; Neuromuscular-system-disorders; Neuropathology; Neuropathy; Neurophysiological-effects; Neurophysiology; Neurotoxic-effects; Neurotoxicity; Neurotoxicology; Neurotoxins; Blood-samples; Blood-sampling
Contact
Ernest Hodgson, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh NC 27695, USA
CODEN
JBMTFQ
CAS No.
2921-88-2; 63-25-2; 333-41-5
Publication Date
20050601
Document Type
Journal Article
Email Address
ernest-hodgson@ncsu.edu
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-0077551
Issue of Publication
3
ISSN
1095-6670
Source Name
Journal of Biochemical and Molecular Toxicology
State
NC
Performing Organization
North Carolina State University-Raleigh
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