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Peripheral eosinophils are associated with new onset and persistent wheezing and dyspnea in World Trade Center exposed individuals.

Authors
Maa-M; Kazeros-A; Turetz-ML; Parsia-SS; Caplan-Shaw-CE; Walter-D; Liu-M; Rogers-L; Marmor-M; Reibman-J
Source
Am J Respir Crit Care Med 2010 May; 181(Meeting Abstracts):A4691
NIOSHTIC No.
20037191
Abstract
Rationale: Eosinophilic inflammation is one component of the complex inflammatory response in asthma, and elevations in lung and peripheral eosinophils (eos) are reported in subpopulations with refractory asthma. Some exposed to World Trade Center (WTC) dust and fumes developed complex lung disease with many, but not all, having symptoms (sx) consistent with irritant-induced asthma. We hypothesized that persistent asthma-like sx in WTC-exposed individuals would be associated with systemic inflammation characterized by peripheral eos. Methods: Individuals with physical sx occurring after WTC dust/fume exposure were self-referred to the WTC Environmental Health Center (EHC), a program for residents, local workers, and clean-up workers. All individuals underwent a standardized evaluation including blood work. There were 2461 individuals treated between 9/2005-3/2009. Individuals with respiratory sx or asthma diagnosis prior to 9/11, current tobacco use or a >5 p-y tobacco history were excluded. Results: Analysis was performed on 1508 individuals who met inclusion criteria. Individuals had a mean age of 47 years, were mostly female (51%), and had a diverse race/ethnicity. Many (41%) were caught in the initial WTC dust cloud from the collapsing buildings. Respiratory symptoms that developed after WTC dust/fume exposure (new onset) and were present within the month preceding entry into the WTC EHC (persistent) included cough (55%), chest tightness (45%), wheeze (32%) and dyspnea on exertion (DOE; 26%). Both absolute and percent peripheral eos were elevated in patients with wheezing compared to those without (3.03 + 0.1 vs 2.42 + 0.1 % eos, mean + SEM respectively, p <0.0001) Percent peripheral eos were elevated in patients with new onset and persistent DOE compared to those without DOE ( 2.75 + 0.01 vs 2.39 + 0.1 % eos respectively (p< 0.004). Additionally, FEV1 was reduced in patients with > 4% eos (n = 203) compared to those with < 4% eos (n = 1205) (89.0 vs 93.0% predicted FEV1 respectively, p < 0.04). Conclusions: Peripheral eos were associated with specific respiratory sx of wheeze and DOE as well as reduced lung function in a diverse WTC-exposed population. These data suggest that eosinophils may participate in lung inflammation in this WTC exposed population with sx consistent with irritant-induced asthma.
Keywords
Airborne-particles; Airway-obstruction; Allergens; Bacterial-dusts; Bacteriology; Biological-effects; Biological-monitoring; Breathing; Cell-biology; Cellular-function; Cellular-reactions; Dust-analysis; Dust-counting; Dust-exposure; Dust-inhalation; Dust-measurement; Dust-particles; Dusts; Dust-sampling; Environmental-contamination; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-pollution; Exposure-assessment; Exposure-levels; Exposure-methods; Immune-system; Immunodiagnosis; Inhalants; Inhalation-studies; Lung; Lung-disease; Lung-disorders; Lung-fibrosis; Lung-function; Lung-irritants; Microscopic-analysis; Particle-aerodynamics; Particle-counters; Particulate-dust; Particulates; Public-health; Pulmonary-disorders; Pulmonary-function; Pulmonary-function-tests; Pulmonary-system; Pulmonary-system-disorders; Quantitative-analysis; Respirable-dust; Respiratory-function-tests; Respiratory-hypersensitivity; Respiratory-infections; Respiratory-irritants; Respiratory-system-disorders; Risk-analysis; Risk-factors; Smoking; Spirometry; Statistical-analysis; Tobacco; Toxic-effects; Work-environment; Workplace-studies
CODEN
AJCMED
Publication Date
20100501
Document Type
Abstract
Funding Type
Grant
Fiscal Year
2010
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-E11-OH-009630
ISSN
1073-449X
Source Name
American Journal of Respiratory and Critical Care Medicine
State
NY
Performing Organization
New York City Health and Hospitals Corporation
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